HDFN

Question 1

Before the invention of this medication, about 95% of the cases of HDFN is caused by antibodies against Rh. What is this medication?

Answer 1

Rh immune globulin

Question 2

2. Enumerate the factors influencing ABO HDFN during pregnancy.

Answer 2

Tetanus toxoid
Helminthic parasite infection

Question 3

4. What lifesaving procedure needs to be done in order to hinder the occurrence of kernicterus?

Answer 3

Exchange transfusion

Question 4

What do you call the type of brain damage that can result from high level of bilirubin in the newborn’s blood?

Answer 4

Kernicterus

Question 5

What is the type of HDFN that is not predicted by antibody titer?

Answer 5

ABO HDFN

Question 6

In 1991, what is the incidence rate of Rh HDFN per 10,000 total births?

Answer 6

10.6

Question 7

What is the expected reticulocyte count in late hyporegenerative anemia?

Answer 7

Low or absent

Question 8

This test is done because the mother’s blood type may not accurately reflect the fetal RhD status, especially if the mother has previously been exposed to RhD-positive blood.

Answer 8

Paternal testing

Question 9

This phenomenon occurs when an expectant mother is RhD-negative but the father and the baby are RhD-positive and sensitization may occur during her fist pregnancy.

Answer 9

Blocking phenomenon

Question 10

When exposed to temperature changes, it collapses structures within the umbilical cord; thus, provides a physiological clumping of the cord. Typically, 3 minutes after birth can yield false-positive results when it is not totally removed/washed before the testing.

Answer 10

Wharton’s jelly

Question 11

A rare of the Rh HDFN wherein accurate testing can be difficult if the red cells are heavily coated with IgG anti-D antibodies.

Answer 11

Blocking phenomenon

Question 12

This is also sometimes called percutaneous umbilical cord blood sampling, a test that examines blood from the fetus to detect fetal abnormalities.

Answer 12

Cordocentesis

Question 13

kernicterus is a type of brain damage that can result from high levels of bilirubin in the baby’s blood. This is also called as ______.

Answer 13

Bilirubin encephalopathy

Question 14

A procedure in which cells covered with antibodies undergo treatment to break the connections between antigens and antibodies. It is usually done in patients who are already sensitized.

Answer 14

Elution

Question 15

What is the standard dose of RhIG in the US? Express in μg and IU.

Answer 15

300 μg, 1,500 IU

Question 16

What is the regular dose of RhIG in the UK? Express in μg and IU.

Answer 16

100 μg, 500 IU

Question 17

The purpose of RhIG treatment is to neutralize Rh-positive fetal red cells that have entered to an Rh-negative mother through the placenta preventing what?

Answer 17

Rh sensitization

Question 18

In antenatal care, RhIG will be administered in the ___ of pregnancy and how many weeks of gestation?

Answer 18

3rd trimester, 28 weeks

Question 19

In the postpartum period, based on historical experiments, what is the recommended timeframe in administering RhIG after delivery?

Answer 19

Within 72 hours after delivery

Question 20

What does FMH stands for?

Answer 20

Fetomaternal hemorrhage

Question 21

What type of method is used to determine the amount of fetomaternal hemorrhage?

Answer 21

Quantitative method

Question 22

In situations where serologic reagents cannot accurately identify RhD types especially in weak D phenotypes, what detection test is preferred?

Answer 22

Maternal weak D

Question 23

It is derived from pooled human plasma of hyperimmunized patients containing IgG anti-D and a minimal amount of Rh- positive proteins.

Answer 23

Rh immune globulin

Question 24

What is the expected bilirubin in Early onset anemia

Answer 24

Elevated

Question 25

What is the expected bilirubin in late hemolytic anemia

Answer 25

Usually elevated

Question 26

What is the expected bilirubin in Late hyporegenerative anemia

Answer 26

Normal

Question 27

What is the expected reticulocyte count of late hemolytic anemia

Answer 27

Norma or high

Question 28

What is the expected reticulocyte count of early onset anemia

Answer 28

Normal or high