HDFN Flashcards
Before the invention of this medication, about 95% of the cases of HDFN is caused by antibodies against Rh. What is this medication?
Rh immune globulin
- Enumerate the factors influencing ABO HDFN during pregnancy.
Tetanus toxoid
Helminthic parasite infection
- What lifesaving procedure needs to be done in order to hinder the occurrence of kernicterus?
Exchange transfusion
What do you call the type of brain damage that can result from high level of bilirubin in the newborn’s blood?
Kernicterus
What is the type of HDFN that is not predicted by antibody titer?
ABO HDFN
In 1991, what is the incidence rate of Rh HDFN per 10,000 total births?
10.6
What is the expected reticulocyte count in late hyporegenerative anemia?
Low or absent
This test is done because the mother’s blood type may not accurately reflect the fetal RhD status, especially if the mother has previously been exposed to RhD-positive blood.
Paternal testing
This phenomenon occurs when an expectant mother is RhD-negative but the father and the baby are RhD-positive and sensitization may occur during her fist pregnancy.
Blocking phenomenon
When exposed to temperature changes, it collapses structures within the umbilical cord; thus, provides a physiological clumping of the cord. Typically, 3 minutes after birth can yield false-positive results when it is not totally removed/washed before the testing.
Wharton’s jelly
A rare of the Rh HDFN wherein accurate testing can be difficult if the red cells are heavily coated with IgG anti-D antibodies.
Blocking phenomenon
This is also sometimes called percutaneous umbilical cord blood sampling, a test that examines blood from the fetus to detect fetal abnormalities.
Cordocentesis
kernicterus is a type of brain damage that can result from high levels of bilirubin in the baby’s blood. This is also called as ______.
Bilirubin encephalopathy
A procedure in which cells covered with antibodies undergo treatment to break the connections between antigens and antibodies. It is usually done in patients who are already sensitized.
Elution
What is the standard dose of RhIG in the US? Express in μg and IU.
300 μg, 1,500 IU
What is the regular dose of RhIG in the UK? Express in μg and IU.
100 μg, 500 IU
The purpose of RhIG treatment is to neutralize Rh-positive fetal red cells that have entered to an Rh-negative mother through the placenta preventing what?
Rh sensitization
In antenatal care, RhIG will be administered in the ___ of pregnancy and how many weeks of gestation?
3rd trimester, 28 weeks
In the postpartum period, based on historical experiments, what is the recommended timeframe in administering RhIG after delivery?
Within 72 hours after delivery
What does FMH stands for?
Fetomaternal hemorrhage
What type of method is used to determine the amount of fetomaternal hemorrhage?
Quantitative method
In situations where serologic reagents cannot accurately identify RhD types especially in weak D phenotypes, what detection test is preferred?
Maternal weak D
It is derived from pooled human plasma of hyperimmunized patients containing IgG anti-D and a minimal amount of Rh- positive proteins.
Rh immune globulin
What is the expected bilirubin in Early onset anemia
Elevated
