AIHA Flashcards
is defined as shortened red blood cell (RBC) survival mediated through the immune response, specifically by humoral antibody.
Immune hemolytic anemia
How many percent of AIHA are warm type
70%
Unusual type of WAIHA
IgM warm autoantibodies
What is the most reliable technique in detecting IgM warm autoantibodies
Flow cytometry
This are antibodies that cause red blood cells (RBCs) to clump together at cold temperatures.
Cold agglutinin
Cold agglutinin disease, also known as
Cold hemagglutinin disease or idiopathis cold AIhA
Cold agglutinin disease, also known as cold hemagglutinin disease (CHD) or idiopathic cold AIHA reacts optimally at 4°C but can also react at higher temperatures between
25-30 Degree celsius
The Antibody specificity in this Cold agglutininn disease is almost always
Anti I
It is the blue discoloration of the hands, feet, ears, and nose caused by constricted blood vessels.
Acrocyanosis
True or False
Patients affected by cold hemagglutinin disease (CHD) typically exhibit symptoms commonly associated with chronic anemia, including weakness, pallor or paleness, and weight loss.
True
is a rare autoimmune disorder causing cold-induced hemolysis and hematuria.
Paroxysmal Cold Hemoglobinuria
It is a cold autoantibody called a biphasic autohemolysin prompts the breakdown of red blood cells (RBCs).
Paroxysmal Cold Hemoglobinuria
The antibody specificity is only demonstrated in the _____________ which is the test used to confirm the diagnosis of PCH
Donath-Landsteiner test
Autoantibody class of PCH
IgG(anti-P , biphasic hemolysin)
Autoantibody class of CHD
IgM (anti I/i), monophasic
