Haematology Flashcards
What haematological condition has increased granulocytes at different stages of maturation?
Chronic myeloid leukaemia
What is acute chest syndrome a complication of and how does it present?
Sickle cell disease
Dyspnoea, chest pain, cough, hypoxia and new pulmonary infiltrates seen on X-ray
What is the haemoglobin, MCV and reticulocyte combination you would expect in sickle cell disease?
Normocytic anaemia
Low HB
Normal MCV
Raised reticulocytes
What condition has auer rods and myeloid blast cells?
AML
What test is most useful in diagnosis in polycythaemia vera?
JAK2 mutation
What is the treatment for warm autoimmune haemolytic anaemia?
Steroids
What is the most common type of Hodgkins lymphoma?
Nodular sclerosing
What is the reversal agent for dabigatran?
Idarucizumab
What is the first line management of CML?
Imatinib
What is the reversal agent for riveroxaban and apixaban?
Adexanet alfa
What is the reversal agent for dabigatran?
Idarucizumab
What antibiotic increases INR of a patient taking warfarin?
Clarithromycin
What is seen on a blood film of hyposplenism?
Howell-Jolly bodies
What is raised in patients with beta thalassaemia major?
HbA2
When should sickle cell patient have pneumococcal vaccine?
Every 5 years
What immunoglobulin deficiency poses a risk for anaphylaxis being more likely in blood transfusion?
IgA
What blood products are more likely to have bacterial contamination?
Platelet concentrate
What is heparin overdose treatment?
Protamine sulphate
What organisms cause post splenectomy sepsis?
Strep pneumonia
H. Influenzae
Meningococci
What is the treatment for beta thalassaemia major?
Life long blood transfusions
Iron chelation therapy
What is the most common disease for CLL to turn into?
Non-hodgkins lymphoma
What are the features of polycythaemia vera?
Raised haemoglobin, plethoric appearance, pruritic, splenomegaly, hypertension
