Haematology

Question 1

Antiphospholipid syndrome blood results

Answer 1

Low platelets, prolonged APTT
Positive anticardiolipin antibodies, anti-beta2 glycoprotein antibodies + lupus anticoagulant

Question 2

Antiphospholipid management

Answer 2

Primary prevention - aspirin
Secondary prevention for VTE - warfarin
Can add in aspirin to warfarin if still having VTEs

Question 3

Antiphospholipid presentation

Answer 3

Recurrent miscarriage
Venous and arterial thrombosis

Question 4

What condition can antiphospholipid syndrome be secondary to?

Answer 4

SLE

Question 5

Most common inherited cause of thrombophilia

Answer 5

Factor V Leiden

Question 6

Acute haemolytic reaction symptoms

Answer 6

Fever, abdominal pain, hypotension

Question 7

TACO symptoms

Answer 7

Hypoxia and hypotension

Question 8

TRALI symptoms

Answer 8

Hypoxia, fever, and hypotension

Question 9

Myelofibrosis pathophysiology

Answer 9

Myeloproliferative disorder
Hyperplasia of abnormal megakaryocytes
Platelet derived growth factor stimulates fibroblasts
Haematopoiesis in liver and spleen

Question 10

Myelofibrosis presentation

Answer 10

Elderly
Anaemia symptoms
Splenomegaly
Weight loss
Night sweats

Question 11

Myelofibrosis investigations

Answer 11

Anaemia
High WCC and plt
Tear drop poikilocytes on blood film
Unobtainable bone marrow biopsy
High urate and LDH (increased cell turnover)