haem Flashcards
coag profile for von willebrands disease
APTT and bleeding time prolonged
which blood product carries highest risk of contamination and why
platelets as they are stored at room temp
blood film in coeliac disease
howell jolly
target cells
due to hyposplenism
blood film of myelofibrosis
tear drop poikilocytes
reversal for rivaroxaban and apixaban
andexanet alfa
blood smear for acute promyelocytic leukaemia shows
auer rods
tx for acute chest syndrome
pain relief
oxygen therapy
antibiotics
transfusion
PCV can progress to?
myelofibrosis
AML
aplastic crisis ix results
sudden drop in HB
with low reticulocyte count
= acute bone marrow failure
due to parvovirus B19 in sickle cell patients
blood film of G6PDH
bite and blister cells
TIBC in iron def anaemia
increases as body produces more transferrin to maximise iron uptake
what is transferrin
iron transport molecule
transfusion packed red cell threshold for patients with ACS
<80g/L
target after transfusion
80-100
how can you tell the diff between an aplastic crisis and sequestration crisis in sickle cell
Aplastic crisis has reduced reticulocytes, whereas sequestration crisis has increased reticulocytes
what symptoms point towards a cold AIHA
1) Background a lymphoma (risk factor for cold AIHA)
2) Raynaud’s phenomenon
3) Symptoms worse in the cold
4) New macrocytic anaemia, the macrocytosis here is occurring due to reticulocytosis (new immature RBCs which are larger) to compensate for the haemolysis.
what is acute intermittent polyporphia
autosomal dominant
defect in porphobilinogen deaminase
symptoms AIP
abdominal: abdominal pain, vomiting
neurological: motor neuropathy
psychiatric: e.g. depression
hypertension and tachycardia common
5x more likely in females
diagnosis and mx of AIP
urine turns deep red on standing
raised urinary porphobilinogen
avoid triggers
IV haem arginate
IV glucose if this isn’t avail
what to screen for before starting rituximab
hep B
