Gynecology Flashcards
cervical cancer path
HPV infection -> 16, 18, 30s
cervical cancer pt
asx screen = pap (pre-cancer)
post-coital bleeding
reproductive age female
cervical cancer dx
pap smear - start screen @ 21, then q3y - ASCUS: q1y Pap or HPV DNA colposcopy - ectocervical lesions - endocervical lesions staging
cervical cancer tx
ecto: local ablation (LEEP, cryo)
endo: cone biopsy
stage IIa or < : local resection
stage IIb or > : chemo + radiation
cervical cancer screen
pap smear
cervical cancer ppx
HPV vax 11-26
endometrial cancer path
PROgesterone is PROtective Estrogen Exposure - old age - nulliparity - obesity - PCOS - HRT
endometrial cancer pt
postmeno female with postmeno bleeding
endometrial cancer dx
endometrial sampling or D&C (bx)
endometrial cancer tx
hyperplasia: progesterone
cancer: TAH + BSO
+/- radiation
+/- chemo
vulvar cancer path
squamous cell (HPV) melanoma (sun exposure)
vulvar cancer pt
black and itchy
vulvar cancer dx
1st and best = bx
vulvar cancer tx
vulvectomy and LN dissection
paget’s path
usually noninvasive
paget’s pt
RED and itchy
paget’s dx
1st and best = bx
paget’s tx
local resection (no need for vulvectomy)
germ cell ovarian cancer subtypes
dysgerminomas: chemo, LDH
endometrial sinus: AFP
teratoma: struma ovarii
chorio: ß-hCG
germ cell ovarian cancer path
nonmalignant
germ cell ovarian cancer pt
teenge girl with an adnexal mass
stage I
germ cell ovarian cancer dx
TVUS
best: biopsy
germ cell ovarian cancer tx
unilateral salpingo-oopherectomy (conservative)
epithelial cell ovarian cancer subtypes
serous
mucinous
endometrioid
brenner’s
epithelial cell ovarian cancer path
epithelial trauma = ovulation
malignant
epithelial cell ovarian cancer pt
postmeno female null/low parity stage IIIb or worse (even w/ screen) - asx, seed peritoneally - renal failure, SBO, ascites BRCA1 or 2, HNPCC
epithelial cell ovarian cancer dx
NO screen
1st: TVUS
then: CT - stage
track: CA 125
best: bx
epithelial cell ovarian cancer tx
TAH + BSO
paclitaxel
epithelial cell ovarian cancer special
BRCA1 or 2 screen
- TVUS and CA-125 w/ ppx TAH+BSO @35
stromal cell ovarian tumors
granulosa theca - estrogen
sertoli leydig - testosterone
vaginal cancer - SCC
just like cervical cancer except no pap
vaginal cancer - adeno
DES exposure in mom while your patient in front of you was in mom’s uterus
‘grape-like’ mass in vagina in a child
complete mole path
completely molar = no fetal parts completely chromosomal = 46, XX completely spermal =no egg genetics normal fertilization broken egg
complete mole pt
size-date discrepancy ß-hCG too high for dates hyperthyroidism (from ß-hCG) hyperemesis gravidarum adnexal mass (simple cyst) grape-like mass exiting cervix
complete mole dx
1st: U/S = snowstorm **
complete mole tx
suction curettage
complete mole f/u
ß-hCG q week
OCP x1y
incomplete mole path
incompletely molar = some fetal parts
incompletely chromosomal = t69, XXY
abnormal fertilization = 2 sperm
normal egg
incomplete mole pt
size-date discrepancy ß-hCG too high for dates hyperthyroidism (from ß-hCG) hyperemesis gravidarum adnexal mass (simple cyst) grape-like mass exiting cervix
incomplete mole dx
US snowstorm
incomplete mole tx
suction curettage
incomplete mole f/u
ß-hCG q1wk
OCP x1y
choriocarcinoma path
cancer of gestational contents
choriocarcinoma pt
s/p mole, miscarriage, or even normal pregnancy
increase ß-hCG (sxs as above)
choriocarcinoma dx
1st: TVUS
best: biopsy = curettage
then: stage CT
choriocarcinoma tx
surgical -TAH (I) - debulking (II) medical = "MAC" - MTX - actinomycin D - cyclophosphamide chemo = "MAC backbone" - advanced only
stress incontinence path
big/multiple births
stretch cardinal ligament
cystocele
abd pressure on = bladder, not sphincter
stress incontinence pt
sneeze and pee
no urge
no nocturnal sxs
stress incontinence dx
physical = cystocele
Qtip test
stress incontinence tx
1st: lifestyle
then PT, pessaries
then surgery (sling/urethral bulking agents)
hypertonic bladder/motor urge path
spastic contractions
random detrusor contractions
hypertonic bladder/motor urge pt
+ urge
+ nocturnal sxs
pee when spasms
hypertonic bladder/motor urge dx
physical = normal u/a = normal cystometry = spasms at all urinary volumes
hypertonic bladder/motor urge tx
oxybutynin
intermittent/indwelling catheter
hypertonic bladder/motor urge f/u
too much antispasmodics -> hypotonic
hypotonic bladder/overflow incontinence path
absent detrusor muscle contractions
neural injury = trauma, MS, etc
leaks before ruptures
hypotonic bladder/overflow incontinence pt
no urge to void
+ nocturnal sxs
leak throughout day
hypotonic bladder/overflow incontinence dx
physical = normal .l. focal neurologic deficit u/a = normal cystometry = no spasms at any volume
hypotonic bladder/overflow incontinence tx
bethanechol
intermittent/indwelling catheter
irritative bladder path
inflammation
stones, UTI, cancer
irritative bladder pt
frequency, urgenc,y dysuria
+ urge
no nocturnal sxs
irritative bladder dx
physical = normal u/a = dx -> urine cx
irritative bladder tx
UTI: FQ, bactrim, nitrofurantoin
irritative bladder f/u
stones and cancer (urology, medicine)
dermoid cyst/teratoma path
benign tumor of ovary
dermoid cyst/teratoma pt
young woman (teens) abdominal/adnexal mass weight gain
dermoid cyst/teratoma dx
u/s = complex cyst
dermoid cyst/teratoma tx
cystectomy (this cyst only)
dermoid cyst/teratoma f/u
likely to recur on the opposite side
endometrioma path
retrograde menses?
estrogen responsive tissues
endometrium outside the uterus
endometrioma pt
dysmenorrhea
dyspareunia
infertility
endometrioma dx
u/s = cyst
dx lap with laser ablation
OCP trial
endometrioma tx
- pelvic pain: NSAIDs
- axis: OCPs -> GnRh analogues -> danazol
- dx lap with laser ablation
endometrioma f/u
chocolate cyst
ectopic pregnancy path
salpingitis (PID) = stricture
early fertilization
ampulla is mos common site
ectopic pt
amenorrhea/spotting
abd pain
UPT +
ectopic dx
UPT +
ß-hCG >/= 2000
U/s = ectopic
ectopic tx
salpingostomy: no rupture
salpingectomy: + rupture
MTX +/- leucovorin
- ß-hCG < 5000
- GS < 3cm
- no heart tones
ectopc f/u
trend hCG to 0..risk of chorio
tubo-ovarian abscess path
PID = Gc/Chla
vaginal flora
TOA pt
abd/pelvic pain no other cause 1 of 3: - CMT - adnexal tenderness - uterine tenderness fever, leukocytosis \+ wbc on wet prep ^^^^^
TOA dx
u/s = abscess, complex cyst
TOA tx
inpatient IV - cefoxitin + doxy + MTZ - clinda + genta drain - if abx fail
TOA f/u
drain if no improvement
cefoxitin + doxycycline are for PID
ovarian torsion path
ovary twists about the vascular supply and kills off the ovary
weight of the cysts, twists around the suspensory ligament
ovarian torsion pt
spontaneous abdominal pain
toxic (fever, leukocytosis)
no good reason why
ovarian torsion dx
u/s with doppler = decreased flow
ovarian torsion tx
operate = untwist
- pinks up: leave it in
- stays grey: cut it out
simple cysts
single, fluid filled, homogenous cystic unilocular < 7cm resolved in 2 mo treat with OCP
complex cysts
loculated, lobulated, multiple septations solid, mixed multilocular >/= 7cm won't resolve already on OCP at dx