Endocrinology Flashcards
what is secreted from hypothalamus?
GnRH
TRH
CRH
CHRH
where does GnRH act
anterior pituitary -> FSH/LH
where does TRH act
anterior pituitary -> TSH
where does CRH act
anterior pituitary -> ACTH
where does GHRH act
anterior pituitary -> GH
where does FSH/LH act
ovaries -> estrogen, progesterone, ovulation
where does TSH act
thyroid -> T3, T4, metabolism
where does ACTH act
adrenals -> cortisol, stress
where does GH act
liver -> IGF-1, growth
prolactinoma path
autonomously secreting prolactin
most common pituitary lesion
prolactinoma pt
women: galactorrhea, amenorrhea, micro adenoma, no vision change
men: decreased libido, gynecomastia, macro adenomas, vision changes
prolactinoma dx
1st: TSH/fT4
then: prolactin levels
best: MRI
prolactinoma tx
bromocriptine or cabergoline
surgery
prolactinoma f/u
surgery is NOT first line therapy for prolactinomas
- it is for all other secreting pituitary tumors and macroadenomas
acromegaly path
growth hormone = things that grow
child = long bones (gigantism)
adult = visceral organs
acromegaly pt
cardiomegaly -> DIA heart failure diabetes wide-spaced teeth hat/ring/shoe size increases coarse features, carpal tunnel big hands
acromegaly dx
IGF-I
glucose suppression test
MRI
acromegaly tx
surgery first
octreotide or cabergoline (adjunct)
acromegaly f/u
glucose suppression test = give glucose, test is positive (abnormal) if the GH does not change
acromegaly wait
carpal tunnel is more associated with RA than acromegaly, don’t be tricked
acute pan hypopituitarism path
infection, infarction, surgery, rads
acute pan hypopituitarism pt
TSH: lethargy, coma
ACTH: hypotension, tachycardia
GH/LH/FSH: irrelevant
acute pan hypopituitarism dx
clinical
hormone (cortisol and T4)
acute pan hypopituitarism tx
replace end hormones
acute pan hypopituitarism f/u
Sheehan’s: pregnancy, bloody delivery
Apoplexy: tumor outgrows blood supply and dies, necrosis
chronic pan hypopituitarism path
autoimmune, deposition, cancer
GH/FSH/LH sacrificed so that TSH and ACTH can persist
chronic pan hypopituitarism pt
decrease libido, changes in menstruation
decrease growth
chronic pan hypopituitarism dx
insulin stimulation test
- growth hormone fails to rise
MRI
chronic pan hypopituitarism tx
reverse underlying cause
replace hormones prn
empty sella syndrome path
normal variant
empty sella syndrome pt
asymptomatic
empty sella syndrome dx
MRI
empty sella syndrome tx
reassurance
SIADH path
too much ADH = too much water = patient becomes hypotonic
brain lesion = increase ADH
lung lesion = increase ADH (small cell, PNA)
SIADH pt
hyponatremia
SIADH dx
UNa increase
Uosm increase
Sosm decrease
SIADH tx
water restriction
demeclocycline
reverse underlying disease
central diabetes insipidus path
central: no ADH production
central diabetes insipidus pt
polydipsia
polyuria
normal blood glucose
central DI dx
water deprivation test
- corrects with ADH = central DI
central DI tx
intranasal desmopressin (DDAVP)
nephrogenic DI path
dysfunctional ADH receptor
nephrogenic DI pt
polydipsia
polyuria
normal blood glucose
nephrogenic DI dx
water deprivation test
-FAILS to correct
nephrogenic DI tx
gentle diuresis
psychogenic polydipsia path
excess free water intake causes medullary wash out
psychogenic polydipsia pt
polyuria
polydipsia
normal blood glucose
psychogenic polydipsia dx
water deprivation test
- corrects with water restriction
psychogenic polydipsia tx
stop drinking so much
when to use FNA for thyroid nodule
best test except excisions biopsy
if any doubt - get an FNA
when to use TSH for thyroid nodule
nodule suspected of being hot/active
when to use RAIU for thyroid nodule
if not sure, either before or after FNA to push one way or the other
when to use U/S for thyroid nodule
assess nodule before FNA, identify good sites for biopsy. confirm index of suspicion
papillary thyroid cancer need to knows
most common
associated with XRT
orphan-annie nuclei and psammoma bodies
papillary architecture (FNA), h/o head and neck cancer
positive prognosis (slow growing) -> resection
follicular thyroid cancer need to knows
tumor difficult to dx on bx, looks normal
spreads hematogenously
tx resection and I2 ablation
medullary thyroid cancer need to knows
C-cells producing calcitonin -> hypo-Ca
part of MEN2a and MEN2b genetics
anaplastic thyroid cancer need to knows
found in elderly patients
grows locally and quickly
dismal px correlates to degree of anaplasia
MEN1 path
autosomal dominant MEN1
MEN1 pt
pancreas -> gastrinoma, insulinoma
pituitary -> any pituitary
parathyroid -> hyper-Ca
MEN2A path
RET
MEN2A pt
pheochromocytoma
thyroid
parathyroid
MEN2B path
RET
MEN2B pt
pheochromocytoma
thyroid
neuronal