Cardiology Flashcards
pathology of myocardial infarction
occlusion of a coronary vessel
patient presentation of myocardial infarction
chest pain that is worse with exertion, better with rest, relieved with nitrates in a hypertensive, diabetic, dyslipidemic smoker, who is old
diagnosis of myocardial infarction
ST segment changes = STEMI
biomarker elevation = NSTEMI
Stress test = CAD
Coronary angiogram = best test
treatment of myocardial infarction
MONA = morphine, oxygen, nitrates, aspirin
BASH = ß blocker, ACE-i, statin, heparin
Coronary angiography with stent (single vessel disease)
CABG (multi-vessel disease)
tPA if no transport available (>60mins)
risk factors and goals for myocardial infarction
HTN = <140/90 Diabetes = A1c < 7.0 Smoking = cessation dyslipidemia = LDL <100, better <70; HDL > 40, better > 60 age = women >55, men >45
story of MI
left-sided/substernal
worse with exertion
better with rest
physical exam of MI
nonpositional
nonpleuritic
nontender (not reproducible)
Pain, relief, trops, ST changes in stable angina
Pain = exercise
relief = rest + nitrates
trops = negative
ST changes = none
Pain, relief, trops, ST changes in unstable angina
pain = @ rest
relief = none
trops = negative
ST changes = none
Pain, relief, trops, ST changes in NSTEMI
pain = @ rest
relief = none
trops = elevated
ST changes = none
Pain, relief, trops, ST changes in STEMI
pain = @ rest
relief = none
trops = increased
ST changes = elevated
ACUTE treatment options in MI
ASA = first drug to give
Nitrates = second
Angioplasty = no clopidogrel needed, only in single-vessel disease
Bare-metal stent = clopidogrel x1mo, only in single-vessel disease
Drug-eluting stent = clopidogrel x1yr, only in single-vessel disease
CABG = left mainstem equivalent or multi-vessel disease
tPA = no PCI is available within 60mins transport time
Door-to-ballon = 90mins
door to balloon time in MI
90 mins
chronic treatment options in MI
ß blocker = <140/90, HR <70 ACE-i = BP <140/90 Aspirin = antiplatelet Clopidogrel = antiplatelet Statins = LDL < 100 (prefer <70)
imaging in MI
EKG = test of choice, no baseline abnormality Echo = EKG abnormality, no CABG Nuclear = CABG, Baseline Wall defects, LBBB
stress test
exercise = test of choice, no contraindication to exercise with feet
pharm = any reason why they can’t get on a treadmill of any kind
- dobutamine and adenosine
complications of MI
RV failure = right-sided EKG, NO NITRATES
aneurysm = diagnosed by echo
arrhythmia = vtach/vfib - ventricular ectopy from dying cells; Brady/blocks - AV nodal dysfunction
left sided heart failure
pulmonary edema, shortness of breath, crackles, dyspnea on exertion, orthopnea, paroxysmal nocturnal dyspnea
S3
right sided heart failure
JVD, peripheral edema, abdominal pain
systolic heart failure
floppy (ischemic/chronic), leaky (valves), or dead (ischemic)
depressed ejection fraction
poor forward flow
diastolic heart failure
stiff ventricle, unable to fill
pericardium (tamponade, constrictive pericarditis)
restrictive or hypertrophic cardiomyopathy
NYHA classifications of heart failure
I = no symptoms, unlimited exertional capacity II = slight limitation: comfortable with exertion and rest, but without unlimited capacity (ok ADLs) III = moderate limitation: comfortable at rest only (no ADLs) IV = severe limitations, patient is dyspneic at rest
diagnostic choices for heart failure
cxr ekg bnp 2d echo nuclear angiogram, LV gram angiogram, coronaries
cxr in heart failure
large heart, generally useless
ekg in heart failure
old ischemia, generally useless
bnp in heart failure
if elevated, likely heart failure, but cannot discern left/right, diastolic/systolic
2d echo in heart failure
test of choice
gives much information including EF and diastolic failure, valve lesions
nuclear imaging in heart failure
gives EF and reversible ischemia
angiogram, LV gram in heart failure
gold standard, invasive, generally not needed
angiogram, coronaries
determine CAD state: ischemic cardiomyopathy vs. not
treatments everyone in heart failure gets
ß-blocker, ACE-i
salt restriction <2g NaCl
fluid restrict <2L H2O
treatments in ischemic heart failure
add aspirin, add statin
treatment if EF <35%
must be >/= NYHA III
AICD
treatment in NYHA stage I
ß blocker + ACE-i
treatment in NYHA stage II
BB + ACE-i
loop diuretics
treatment in NYHA stage III
BB + ACE
loop diuretics
hydralazine/isosorbide dinitrate, spironolactone
treatment in NYHA stage IV
BB + ACE
loop diuretics
hydralazine/isosorbide dinitrate, spironolactone
pressors
path of congestive heart failure
systolic vs diastolic
right vs left
ischemic vs non-ischemic
patient in congestive heart failure
dyspnea on exertion, paroxysmal nocturnal dyspnea, orthopnea, peripheral edema, crackles, jvd
diagnosis in CHF
1st: BNP
then: 2D echo = trans thoracic echo
Best: LV ventriculogram
treatment in CHF
systolic: NYHA stage
Diastolic: control BB
grade I murmur
S1, S2 > murmur (murmur is softer)
grade II murmur
S1, S2 = murmur (murmur is equal)
grade III murmur
S1, S2 < murmur (murmur is louder)
grade IV murmur
palpable thrill
grade V murmur
1/2 stethoscope off chest, still audible
grade VI murmur
no stethoscope is needed
when to investigate a murmur
any diastolic murmur
any systolic murmur >/= 3/6 (more than II)
how to investigate murmur
2D echo to evaluate all murmurs
path of mitral stenosis
rheumatic heart disease, stenosis of valve
decreased forward flow during DIASTOLE
atrial stretch
patient with mitral stenosis
Afib with CHF symptoms
opening snap
diastolic decrescendo murmur
diagnosis of mitral stenosis
echo
treatment of mitral stenosis
balloon valvotomy
valve replacement
path of aortic stenosis
calcification, sclerosis of outflow from ventricle
patient with aortic stenosis
old men with atherosclerosis
shortness of breath, syncope, chest pain
crescendo-decrescendo murmur
2nd ICS, R sternal border
diagnosis of aortic stenosis
echo
treatment of aortic stenosis
valve replacement
balloon doesn’t work
follow up for aortic stenosis
CABG assessment if replacing valves
what to think if young person with aortic stenosis
bicuspid aortic valve
path of MVP
congenital defect
patient with MVP
women, especially pregnant
sounds like mitral regard, opening snap
diagnosis of MVP
echo
treatment of MVP
valve replacement
path of mitral regurgitation
acute = infarction, infection, ruptured papillary muscle, chordae tendinae chronic = prolapse, ischemia
patient with mitral regurg
acute = fulminant CHF, hypoxemia, hypotension Chronic = AFib, exertional dyspnea, HOLOSYSTOLIC murmur, radiating to the axilla
diagnosis of mitral regurg
echo
treatment of mitral regurg
valve replacement
path of aortic regurg/insufficiency
ischemia, infection, dissection
patient with aortic regurg
usually sick, hypotension, CHF decrescendo murmur at aortic valve wide pulse pressure water-hammer pulse (bounding) quincke's pulse (nail beds) head bobbing
diagnosis of aortic regurg
echo
treatment of aortic regurg
valve replacement
intra-aortic balloon pump
path of hypertrophic cardiomyopathy
sarcomere defect
pt with HOCM
sudden cardiac death
dyspnea, syncope with exertion
young patient
diagnosis of HCOM
echo
treatment of HOCM
avoid exercise/dehydration
ß-blockade
myotomy
path of dilated cardiomyopathy
decrease contractility
virus, EtOH, ischemia, chemo
pt with dilated cardiomyopathy
systolic CHF: orthopnea, PND, DOE, crackles, dyspnea, JVD
dx of dilated cardiomyopathy
echo = dilated
tx of dilated cardiomyopathy
CHF: BB, ACE-i, diuretics
avoid/stop etoh
avoid/stop chemo
transplant
path of HOCM
genetics, sarcomeres
pt with HOCM
murmur = aortic stenosis
young athletes - sudden cardiac death, syncope, dyspnea on exertion
what increases most murmurs?
leg raise/squat
what decreases most murmurs?
valsalva
what increase HOCM and MVP murmurs?
valsalva
what decreases HOCM and MVP murmurs?
leg raise/squat
why is the mech of murmur different in HOCM and MVP?
increased blood = fill heart more = less obstruction from hypertrophy or valve
dx of HOCM
echo = asymmetric hypertrophy
tx of HOCM
avoid dehydration avoid exercise BB = CCB (rate control) etoh ablation, myectomy AICD if increased risk of death transplant
path of concentric hypertrophic cardiomyopathy
HTN
pt with concentric hypertrophic cardiomyopathy
diastolic CHF
dx of concentric hypertrophic cardiomyopathy
echo = concentric hypertrophy
tx of concentric hypertrophic cardiomyopathy
DIA CHF - avoid dehydration - BB = CCB (Rate) - control BP transplant
path of restrictive cardiomyopathy
amyloid, sarcoid, hemachromatosis, cancer, and fibrosis
pt with restrictive cardiomyopathy
DIA CHF
amyloid -> neuropathy
sarcoid -> pulmonary disease
hema -> cirrhosis, bronze diabetes, CHF
dx of restrictive cardiomyopathy
echo = restrictive
amyloid -> fat pad biopsy
sarcoid -> cardiac MRI -> biopsy
hema -> ferritin -> genetics
tx of restrictive cardiomyopathy
DIA CHF - BB = CHF gentle diuresis transplant underlying disease
etiologies of pericardial disease
infection - viral, bacterial, fungal, TB
autoimmune - rheumatoid arthritis, lupus, Dressler’s, uremia
trauma - penetrating, blunt, aortic dissection
cancer - breast, lung, esophageal, lymphoma
path of pericarditis
viral, uremia
pt with pericarditis
chest pain = pleuritic and positional
dx of pericarditis
1st: EKG shows PR depressions, diffuse ST elevations
best: MRI
tx of pericarditis
NSAIDs + colchicine
NSAIDs - c/I CKD, thrombocytopenia, PUD
colchicine - c/I diarrhea
no longer use steroids
f/u of pericarditis
increase recurrence after steroids
hemodialysis for uremia
path of pericardial effusion
pericarditis
pt with pericardial effusion
pericarditis
dx of pericardial effusion
echo = effusion
tx of pericardial effusion
pericardial window
path of pericardial tamponade
RV cannot fill
pt with pericardial tamponade
JVD + hypotension + decrease heart sounds (Beck’s triad)
clear lungs
pluses paradoxus > 10mmHg
dx of pericardial tamponade
echo
tx of pericardial tamponade
pericardiocentesis