Gut Immunity - Shnyra Flashcards
Paneth cells job
Production of defensins - antimicrobial
M cells job
Luminal antigen sampling, transport intact Microbes and hand off to DC
Plasma cells job
Produce IgA cells
Mucins job and location
glycosylated proteins made by mucosal epithelial cells
Epithelial cells express which TLRs
TLR 2 4 5 6 7 9
How does commensal microflora control inflammation?
Inhibition of NF-kB
Characteristics of GALT
Microvilli Tight junctions Secrete mucins to make glycocalyx Antimicrobial peptides M cells APCs in subepithelial dome
What type of cell for the dominant protective cell-mediated immune response?
Th17
-most numerous
Major form of adaptive immunity in gut that is directed at microbes in lumen is?
IgA
-IgG and IgM in lumen
Major mechanism for controlling responses in gut is?
Treg cells
Lamina propria contains?
IgA and IgM plasma cells
Microflora symbiosis
Balanced
Maintains homeostasis
Microflora dysbiosis
Dysregulation of immune system and inflammation
Due to enviro
What shapes gut microbiota?
Diet
It adapts to diet and changes the nutritional value
Microbiota and immune system co-evolve
Dietary IL?
IL-10
Regulates metabolic activités in lamina propria
2 immune-mediated food allergies?
- Type I - IgE mediated
2. Type III/IV - Non-IgE mediated
4 things related to non-immune mediated food tolerance?
Pharmacological
Enzymatic
Psychosomatic
Irritant
Are you gonna ace this exam?
FUCK yes you are. You amazing beautiful smart future doctor!
2 phases of allergic inflammation
- sensitization induction
2. effector phase
Oral challenge of sensitized individual leads to
Th2 inflammation and allergen induced diarrhea
IL’s associated with allergic diarrhea
IL - 4, 13, 9
Food induced anaphylaxis
Mast cells activated by IgE
Mediators released that induce symptoms include histamine and platelet activating factor
What mediates anaphylaxis to casein?
Ig free light chains
Mediates peanut induced anaphylaxis?
IgG1 - induced activation of macrophages
How else can IgE-mediated mechanisms contribute to shock?
Production of C3a
C3a job
Stimulate macro, baso and mast cells
6 examples of food intolerance
Absence of an enzyme IBS Food poisoning Sensitivity to food additives Recurring stress Celiac disease
In celiac disease, what creates potent immunostimulatory epitopes?
Transglutaminase 2
Presented via HLA-DQ2 or HLA-DQ8
Myofibroblasts in celiac
Remodel mucosal and villus atrophy
Which IL links adaptive to innate immunity?
IL-15
