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Gastrointestinal I > Gut Immunity - Shnyra > Flashcards

Gut Immunity - Shnyra Flashcards

1
Q

Paneth cells job

A

Production of defensins - antimicrobial

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2
Q

M cells job

A

Luminal antigen sampling, transport intact Microbes and hand off to DC

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3
Q

Plasma cells job

A

Produce IgA cells

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4
Q

Mucins job and location

A

glycosylated proteins made by mucosal epithelial cells

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5
Q

Epithelial cells express which TLRs

A

TLR 2 4 5 6 7 9

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6
Q

How does commensal microflora control inflammation?

A

Inhibition of NF-kB

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7
Q

Characteristics of GALT

A 
Microvilli
Tight junctions
Secrete mucins to make glycocalyx
Antimicrobial peptides
M cells
APCs in subepithelial dome
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8
Q

What type of cell for the dominant protective cell-mediated immune response?

A

Th17

-most numerous

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9
Q

Major form of adaptive immunity in gut that is directed at microbes in lumen is?

A

IgA

-IgG and IgM in lumen

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10
Q

Major mechanism for controlling responses in gut is?

A

Treg cells

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11
Q

Lamina propria contains?

A

IgA and IgM plasma cells

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12
Q

Microflora symbiosis

A

Balanced

Maintains homeostasis

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13
Q

Microflora dysbiosis

A

Dysregulation of immune system and inflammation

Due to enviro

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14
Q

What shapes gut microbiota?

A

Diet
It adapts to diet and changes the nutritional value
Microbiota and immune system co-evolve

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15
Q

Dietary IL?

A

IL-10

Regulates metabolic activités in lamina propria

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16
Q

2 immune-mediated food allergies?

A
  1. Type I - IgE mediated

2. Type III/IV - Non-IgE mediated

17
Q

4 things related to non-immune mediated food tolerance?

A

Pharmacological
Enzymatic
Psychosomatic
Irritant

18
Q

Are you gonna ace this exam?

A

FUCK yes you are. You amazing beautiful smart future doctor!

19
Q

2 phases of allergic inflammation

A
  1. sensitization induction

2. effector phase

20
Q

Oral challenge of sensitized individual leads to

A

Th2 inflammation and allergen induced diarrhea

21
Q

IL’s associated with allergic diarrhea

A

IL - 4, 13, 9

22
Q

Food induced anaphylaxis

A

Mast cells activated by IgE

Mediators released that induce symptoms include histamine and platelet activating factor

23
Q

What mediates anaphylaxis to casein?

A

Ig free light chains

24
Q

Mediates peanut induced anaphylaxis?

A

IgG1 - induced activation of macrophages

25
Q

How else can IgE-mediated mechanisms contribute to shock?

A

Production of C3a

26
Q

C3a job

A

Stimulate macro, baso and mast cells

27
Q

6 examples of food intolerance

A 
Absence of an enzyme
IBS
Food poisoning
Sensitivity to food additives
Recurring stress
Celiac disease
28
Q

In celiac disease, what creates potent immunostimulatory epitopes?

A

Transglutaminase 2

Presented via HLA-DQ2 or HLA-DQ8

29
Q

Myofibroblasts in celiac

A

Remodel mucosal and villus atrophy

30
Q

Which IL links adaptive to innate immunity?

A

IL-15

Gastrointestinal I (25 decks)

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