Embryo of Gut (In Class)- Cole Flashcards
what are mesenteries?
reflections of parietal peritoneum onto gut tube
What does the endoderm make?
epithelial lining
what are secondarily reteroperitoneal?
things that had dorsal mesentery
only place that there is ventral mesentery in adults?
liver
3 segments of gut? what do they have?
foregut, midgut, hindgut; have own blood supply and innervation
foregut includes?
esophagus to 1/2 duodenum, liver, gallbladder, pancreas
forgut gets supplied by?
celiac artery
midgut is supplies by?
superior mesenteric artery
hindgut is supplied by?
inferior mesenteric a.
innervation of foregut? where does it synapse?
greater splanchnic n. (T5-9); celiac plexus
midgut is innervated by? synapses?
Lesser Splanchnic (T9-T12)
Parasympathetics to foregut and midgut? synapse where?
vagus n. (CN X); organ walls
parasympathetics to hindgut?
S2-4 (pelvic splanchnic n.)
what kind of defect is an esophageal atresia considered to be?
canalization
hypertrophic pyloric stenosis appears when? as what?
2-3 weeks after birth; projectile, no bilious vomit
where does the liver develop? what else develops there?
ventral mesentery; gallbladder and bile ducts
where does the pancreas develop
buds in both ventral and dorsal mesentery
ventral mesentery gets divided into what 2 parts?
falciform ligament and lesser omentum
ligamentum teres hepatis is the remnant of what?
obliterated left umbilical v.
some of the things that extrahapatic biliary atresia presents with?
jaundice, pale stool, dark urine
treatment of extra-hepatic biliary atresia?
surgical correction or transplant
pdx1 is specific for development of what organ?
pancreas
pax4 regulates what?
cells that secrete insulin, somatostatin, & pancreatic polypeptide
pax 6 regulates?
cells secreting glucagon
how does annular pancreas present?
duodenal obstruction; pancreatic buds form a ring around duodenum
where is ectopic pancreatic tissue most common?
stomach or ileum (ileal or Meckel’s diverticulum)
apple peel atresias are associated with what normally?
vascular problems
by what week does the intestine move back into body?
week 10
what is an intussuception?
part of gut tube tunneled into another part
what is an omphalocele?
herniation of abdominal contents thru enlarged umbilical ring (normal if temporary)
what is gastroschisis?
failure of anterior abdominal wall musculature to close during folding
Prune belly occurs in what sex more frequently?
males
vitelline duct that doesn’t close makes what?
Meckel’s diverticulum, asymptomatic
rule of 2s?
2% prevalance, location 2 feet proximal to ileocecal valve in adults, symptomatic are usually less than 2, 2:1 female predominance?
fecal discharge thru umbilicus is a presentation of?
Meckel’s
Cause of Hirschsprung’s dz?
failure of migration of neural crest cells that form the colonic ganglion cells
where is HD common?
descending and sigmoid colon
if something is primarily reteroperitoneal?
never had a mesentery
where do “high” anal malformations occur?
above pelvic diaphragm
low anorectal malformations are easier to repair why?
because they have some musculature
