Group 9 - Dextrose 50%

Question 1

Dextrose 50%

Drug Class?

Answer 1

Dextrose 50% Drug Class:

• Carbohydrate
• Hyperglycemic

Question 2

Dextrose 50%

Mechanism of Action (MOA)?

Answer 2

Dextrose 50% MOA:

• Reverses CNS effects of hypoglycemia by rapidly increasing serum glucose levels.

Question 3

Dextrose 50%

Indications?

Answer 3

Dextrose 50% Indications:

• Hypoglycemia
• ALOC of unknown etiology
• Seizures of unknown etiology
• Hyperkalemia

Question 4

Dextrose 50%

Contraindications?

Answer 4

Dextrose 50% Contraindications:

• Known thiamine deficiency (relative, if suspected give thiamine)
• Delirium tremens
• Head injury (unless documented hypoglycemia)
• Intercranial hemorrhage (relative)

Question 5

Dextrose 50%

Adverse Reactions?

Answer 5

Dextrose 50% Adverse Reactions:

• Cerebral edema in children when given IV undiluted
• Worsening elevated ICP
• Extravasation leads to severe tissue necrosis

Question 6

Dextrose 50%

Adult Dose?

Answer 6

Dextrose 50% Adult Dose

• Hypoglycemia, ALOC or SZ of unknown etiology: 25-100 ml of D50 (12.5 - 50 Gm) IV.
• Hyperkalemia: 50 Gm of D50 IV administered with calcium chloride and sodium bicarbonate.

Question 7

Dextrose 50%

Pediatric Dose?

Answer 7

Dextrose 50% Pediatric Dose:

• 0.5 - 1 Gm/kg of dextrose 10% solution; recommended slowly over 20 minutes.
• To prepare dextrose 10% , waste 50 ml of normal saline from a 250 ml normal saline “bag” and add 50 ml of dextrose 50%.

Question 8

Dextrose 50%

Onset of Action?

Answer 8

Dextrose 50% Onset of Action:

• Seconds

Question 9

Dextrose 50%

Peak Effects?

Answer 9

Dextrose 50% Peak Effects:

• Variable

Question 10

Dextrose 50%

Duration of Action?

Answer 10

Dextrose 50% Duration of Action:

• Variable

Question 11

Dextrose 50%

AZ Drug Box Minimum Supply?

Answer 11

Dextrose 50% AZ Drug Box Minimum Supply:

• 50 Gm