Group 7 - Lorazepam (Ativan)

Question 1

Lorazepam (Ativan)

Drug Class?

Answer 1

Lorazepam (Ativan)

Drug Class:

• Antiolytic
• Benzodiazepine

Question 2

Lorazepam (Ativan)

Mechanism of Action (MOA)?

Answer 2

Lorazepam (Ativan)

MOA:

• High affinity for the gamma-amino butyric acid (GABA) benzodiazapine receptor complex without displacing GABA
• Tranquilizing action on the CNS

Question 3

Lorazepam (Ativan)

Indications?

Answer 3

Lorazepam (Ativan)

Indications:

• Status epilepticus
• Seizure
• Agitation/excited delirium

Question 4

Lorazepam (Ativan)

Contraindications?

Answer 4

Lorazepam (Ativan)

Contraindications:

• Hypersensitivity
• Acute narrow angle glaucoma
• Pregnancy

Question 5

Lorazepam (Ativan)

Adverse Reactions?

Answer 5

Lorezepam (Ativan)

Adverse Reactions:

• Sedation
• Transient amnesia
• Hypotension
• Respiratory depression
• Dizziness, headache

Question 6

Lorazepam (Ativan)

Adult Dose?

Answer 6

Lorazepam (Ativan)

Adult Dose:

• 2 - 5 mg IV/IO slowly (over 2 - 5 minutes) may repeat in 10 - 15 minutes. Max 10 mg. May give IM if no IV/IO access

Question 7

Lorazepam (Ativan)

Pediatric Dose?

Answer 7

Lorezepam (Ativan)

Pediatric Dose:

• 0.05 - 0.1 mg/kg IV/IO slowly (over 2 - 5 minutes) may repeat in 10 - 15 minutes. Max 4 mg. May give IM if no IV/IO access.

Question 8

Lorazepam (Ativan)

Onset of Action?

Answer 8

Lorazepam (Ativan)

Onset of Action:

• 1 -2 minutes IV/IO

Question 9

Lorazepam (Ativan)

Peak Effects?

Answer 9

Lorazepam (Ativan)

Peak Effects:

• Less than 15 minutes IV/IO

Question 10

Lorazepam (Ativan)

Duration of Action?

Answer 10

Lorazepam (Ativan)

Duration of Action:

• 6 - 8 hours

Question 11

Lorazepam (Ativan)

AZ Drug Box Minimum Supply?

Answer 11

Lorazepam (Ativan)

AZ Drug Box Minimum Supply:

• 8 mg