Group 5 - Diltiazem (Cardizem)

Question 1

Diltiazem (Cardizem)

Drug Class?

Answer 1

Diltiazem (Cardizem) Drug Class:

• Calcium channel blocker
• Calcium antagonist

Question 2

Diltiazem (Cardizem)

Mechanism of Action (MOA)?

Answer 2

Diltiazem (Cardizem)

Mechanism of Action (MOA):

• Decreases SA and AV conduction
• Dilates coronary and peripheral arteries/arterioles

Question 3

Diltiazem (Cardizem)

Indications?

Answer 3

Diltiazem (Cardizem) Indications:

• Rapid ventricular rates associated with atrial fibrillation and atrial flutter
• SVT refractory to adenosine

Question 4

Diltiazem (Cardizem)

Contraindications?

Answer 4

Diltiazem (Cardizem) Contraindications:

• Hypotension (less than 90 mmHg systolic)
• Acute MI
• Cardiogenic Shock
• Wide complex tachycardia, VT
• Wolff-Parkinson-White (WPW) syndrome
• Sick Sinus Syndrome

Question 5

Diltiazem (Cardizem)

Adverse Reactions?

Answer 5

Diltiazem (Cardizem) Adverse Reactions:

• CV: hypotension, bradycardia, heart block, chest pain, asystole
• GI: nausea and vomiting
• CNS: headache, fatigue, drowsiness

Question 6

Diltiazem (Cardizem)

Adult Dose?

Answer 6

Diltiazem (Cardizem) Adult Dose:

• Initial: 0.25 mg/kg IVP (usually 20 mg) administered over 2 minutes
• Repeat: If response inadequate, repeat in 15 minutes with 0.35 mg/kg IVP administered over 2 minutes
• Maintenance Infusion: 5 - 15 mg/hr

Question 7

Diltiazem (Cardizem)

Pediatric Dose?

Answer 7

Diltiazem (Cardizem) Pediatric Dose:

• Safety and efficacy in pediatrics has not been established

Question 8

Diltiazem (Cardizem)

Onset of Action?

Answer 8

Diltiazem (Cardizem) Onset of Action:

• Immediately

Question 9

Diltiazem (Cardizem)

Peak Effects?

Answer 9

Diltiazem (Cardizem) Peak Effects:

• 2 hours or less

Question 10

Diltiazem (Cardizem)

Duration of Action?

Answer 10

Diltiazem (Cardizem) Duration of Action:

• 4 - 6 hours

Question 11

Diltiazem (Cardizem)

AZ Drug Box Minimum Supply?

Answer 11

Diltiazem (Cardizem)

AZ Drug Box Minimum Supply:

• 25 mg