Griseofulvin

Question 1

Drug Class

Answer 1

Anti-fungal

Question 2

Active

Answer 2

Griseofulvin

Question 3

Indications

Answer 3

Dermatophyte infection of: 
    • skin (tinea corporis)
    • scalp and hair (tinea capitis)
    • nails (tinea unguium)
    • feet (tinea pedis)
    • groin (tinea cruris) - where topical treatment has failed or is inappropriate

Question 4

Dose Range

Answer 4

500 – 1000 mg daily

Question 5

SE’s

Answer 5

• GI disturbance (n, v, heartburn, thirst) - common
• photosensitivity
• fatigue
• dizziness
• blurred vision

exacerbation of Lupus eryhematosus, hepatotoxicity (RARE)

Question 6

Counselling

Answer 6

Labels: B, D, 2, 8, 12

• Take with food or milk to increase absorption.
• Griseofulvin may cause dizziness and blurred vision; avoid driving or operating machinery if you are affected.
• Griseofulvin can increase the effects of alcohol, including increasing heart rate and skin flushing; avoid alcohol while you are taking griseofulvin.
• Avoid sun exposure, wear protective clothing and use sunscreen.
• The contraceptive pill will not be as effective while you are taking griseofulvin; you should use additional contraception (eg. condoms, during treatment and for 4 weeks afterwards)
• Males should not conceive within 6 months of treatment.

Question 7

Monitoring

Answer 7

• complete blood count (during prolonged treatment)