gram - rods enteric tract Flashcards by Morgan C

what are enterobacteriaceae located

facultative anaerobes in the normal flora of the LI

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4 common things of enterobacteriaceae

facultative anaerobes, ferment glucose, oxidase negative, convert nitrates to nitrites

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enterobacteriaceae antigens

O, H, K

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enterobacteriaceae endotoxin + or -

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o antigen is an antigenic component of

LPS

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H antigen is an antigenic component on _____

flagellated organisms

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K polysaccharide antigen is aka

capsular antigen

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quellung rxn is with this antigen

k polysaccharide

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what is K polysaccharide in

encapsulated organisms

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Vi antigen causes this

typhoid fever

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most important advances of public health in 20th century

disinfection of public water

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e coli above ___ is unacceptable in fecal contamination

4dL

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MCC urinary tract infections and gram - rod sepsis

e coli

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what dis can e coli cause

UTI, sepsis, neonatal meningitis, watery diarrhea, bloody diarrhea

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“travlers diarrhea”

watery

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MCC travelers diarrhea

etec- enterotoxin e coli

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HUS is mediated by this toxin

shiga

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EHEC? serotype? acquired where?

enterohemorrhagic e coli
O157
acquired in undercooked beef

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e coli characteristics

straight gram - rod
ferments lactose
OHK antigen

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most abundant faculative anaerobe in colon and feces

e coli

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O55 and O111 cause this

neonatal diarrhea

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intestinal tract infection of e coli

pili attach to jejunum and ileum and make enterotoxins

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2 enterotoxins in e coli

heat liable toxin (HT)

heat stable toxin (ST)

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LT stimulates this

adenyl cyclase which inc cAMP and causes watery diarrhea

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tell me about enterotoxin strains of e coli (ETEC)

dont cause inflammation dont invade intestinal mucosa cause watery nonbloody diarrhea

what do shiga toxin producing e coli (STEC) and EHECdo

invade epithelium of LI and cause bloody diarrhea (dysentery) and inflammatory cells (neutrophils) in stool

where are shiga toxin producing e coli (STEC) and EHEC found

undercooked meats and petting zoos

shiga toxin producing e coli (STEC) and EHEC serologic strains

o157:H7

HUS has ____ diarrhea

bloody

HUS consists of...

hemolytic anemia, Thrombocytopenia, acute renal failure

cranberry juice does what

inhibits binding of pili to pyelonephritis associated pili receotors (PAP)

pathogenesis of systemic infection e coli

capsule and endotoxin

what diseases does salmonella cause

enterocolitis, enteric fevers like typhoid fever, septicemia like osteomyelitis

salmonella antigens

O (groups A-I) H (1 and 2) Vi

properties of salmonella

gram - rod dont ferment lactose hydrogen sulfide

categories of salmonella

typhoidal and nontyphoidal

tyhoidal species of salmonella

s typhi and s paratyphi

nontyphoidal species

s enterica

transmission salmonella

ingesting food/water contaiminated by human wastes

MC species of salmonella to cause entercolitis across the US

salmonella typhimurium

enterocolitis?

invasions of epithelial and subepithelial tissue of small and LI

salmonella typhimurium is medited by

invasins

antacids inc chance of infection in

enterocolitis

enterocolitis trmt

self limited, hydration

typhoid/enteric fevers transmission in salmonella

humans

typhoid/enteric fevers in salmonella. where are infections

start in SI, few GI sx, organisms enter phagocytes in peyers patches and are carried to other organisms--> bacteremia typhpoid toxins made in infected cells

what happens if bacteria gets in GB in typhoid/enteric fevers in salmonella

carrier state

typhoid/enteric fevers in salmonella trmt

ceftriaxone or cipro

s typhi vaccines

conjugate- have Vi capsular polysaccharide; give IM | live attenuated- given orally

enterocolitis caused by shigella is AKA

shigellosis or bacillary dysentery

dysnetery?

bloody darrhea

ingestion of ___ can cause shigella

100 orgs

shigella properites

gram - rod nonlactose fermenting o antigen (a, b,c,d)

how to distinguish shigella from salmonella

no gas from fermentation of glucose dont make H2S nonmotile

animal reservioir in shigellosis?

transmission shigellosis?

fecal oral

prolonged carrier state in shigella?

none

diarrhea type in shigella?

bloody

shigella pathogenesis

shiga toxin invades distal ileum and colon causing bloody diarrhea

trmt shigellosis

main: fluid and electrolyte replacement | atb if severe

vaccine shigellosis

none

hallmark of cholera

watery diarrhea in large volumes, rice water stool

cholera toxin

ask pt about travel in ____

cholera

vibrio properties

gram - rod comma shaped O1 and O139

cholera transmission

fecal contamination

cholera main reserviors

marine shellfish, shrimp, oysters

trmt cholera

rehydration | azithromycin

cholera prevention med

totracycline