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GP/hamster/gerbil Flashcards

1
Q

What is the hairless guinea pig?

A

IAF - Institute Armand Frappier

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2
Q

What is the albino guinea pig?

A

Hartley or Dunkin-Hartley

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3
Q

What is the order for rodents?

A

Rodentia

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4
Q

What is suborder for guinea pigs?

A

Hystricomorpha

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5
Q

What is the suborder for mice, rats, and hamsters?

A

Myomorpha

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6
Q

How many digits do Myomorpha have?

A

4 fingers, 5 toes

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7
Q

How many digits do Hystricomorpha have?

A

4 fingers, 3 toes

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8
Q

How many mammae do guinea pigs have?

A

1 pair

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9
Q

How many mammae do mice have?

A

5 pairs

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10
Q

How many mammae do rats have?

A

6 pairs

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11
Q

What is first lab animal species to be axenic (germ-free)?

A

Guinea pig

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12
Q

Name of the test in guinea pigs w/ skin sensitization by contact w/ test substance via patches

A

Buehler

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13
Q

Name of the test in guinea pigs w/ ID inoculation of test substance w/ adjuvant, subsequent exposure of test substance to measure allergic response

A

Kligman (GP maximization test)

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14
Q

Two inbred lines of guinea pigs

A

Strain 2, Strain 13

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15
Q

Rodent dry bulb temp according to Guide

A

68-79F

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16
Q

Who gets tonic immobility due to stress?

A

Guinea pigs

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17
Q

How many chromosomes does mouse have

A

40

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18
Q

How many chromosomes does rat have

A

42

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19
Q

How many chromosomes do different hamsters have

A

Syrian hamster (Mesocricetus auratus) - 44
Chinese hamster (Cricetulus griseus), Armenian hamster (Cricetulus migratorius), European hamster (Cricetus cricetus) - 22
Djungarian (Phodopus campbelli (Russian dwarf) and Phodopus sungorus (Siberian dwarf)) - 28

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20
Q

How many chromosomes do guinea pigs have?

A

32

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21
Q

what is estradiol-dependent mononuclear leukocyte unique to GP and name some characteristics

A

Foa-Kurloff; increases during pregnancy; similar to NK cells; high number in placenta; may be antineoplastic

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22
Q

What do ferret, NHP, and GP WBCs have in common

A

Resistant to steroids (no decrease in lymphocytes after steroid injection)

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23
Q

Dental formula suborder Myomorpha (mouse, rat, hamster)

A

I 1/1 C 0/0 PM 0/0 M 3/3 (16 teeth)

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24
Q

Dental formula guinea pig (Hystricomorpha)

A

I 1/1 C 0/0 PM 1/1 M 3/3 (20 teeth)
All teeth open-rooted

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25
Q

Dental formula rabbit

A

2/1 (peg tooth!) C 0/0 PM 3/2 M 2-3/3 (26-28 teeth)
All teeth open-rooted

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26
Q

Does guinea pig stomach have margo plicatus?

A

No; stomach is all glandular unlike order Myomorpha (mouse/rat/hamster)

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27
Q

Name of startle response in guinea pigs where ear moves in response to noise

A

Preyer or pinna reflex

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28
Q

Which species growth rate is not dependent on pituitary (independent of growth hormone)

A

Guinea pig

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29
Q

sexual maturity of guinea pig

A

female: 350-500g or 5-13 wks
male: 500-800g or 7-13 weeks

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30
Q

Double cervix

A

CHOW-RR (Chinchilla, hamster, opossum, woodchuck, rat, rabbit)

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31
Q

Estrous cycle lengths of rodents and rabbits

A

Mice: 4-5 days
Rats: 4-5 days
Hamster: Syrian, Chinese hamster, and Djungarian 4 days; European hamster 4-6 days
Guinea pig: 16 days
Rabbit: no distinct estrous cycle length

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32
Q

How much water do mice, rats, hamsters drink per day?

A

Mice: 6-7 ml/day
Rats: 8-11 ml/day per 100g
Hamsters: 8.5 ml/day per 100g

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33
Q

Which species has hemomonochorial placenta like humans? (1 layer of trophoblast)

A

Guinea pig

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34
Q

which species gets vaginal closure membrane in anestrus?

A

Hystricomorpha - guinea pig

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35
Q

How much food do mice and rats eat?

A

Mice: 3-5 g/day
Rats: 5 g/day per 100g

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36
Q

Why rabbits and guinea pigs should not be housed together?

A

GPs get Bordetella bronchiseptica with high m&m

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37
Q

Lancefield groups

A

Group C: Strep equi spp zooepidemicus
Group G: commensals
No group: Strep pneumoniae

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38
Q

Cervical, caseous lymphadenitis in guinea pig caused by

A

Strep equi spp zooepidemicus

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39
Q

Fibrinopurulent pericarditis and peritonitis in guinea pigs caused by

A

Strep pneumoniae

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40
Q

Tyzzer’s (Clostridium piliforme) does not affect heart in what species of rodent?

A

Guinea pig

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41
Q

what is cause of guinea pig inclusion conjunctivitis

A

Chlamydia caviae
intracytoplasmic inclusions
Also rhinitis and genital infection
Zoonotic!

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42
Q

Multiple pale nodules in liver and cecum of guinea pig

A

Yersinia pseudotuberculosis
Listeria monocytogenes
Salmonella enterica

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43
Q

cause of respiratory distress and sudden death in guinea pigs

A

Guinea pig adenovirus
basophilic intranuclear inclusion bodies

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44
Q

In guinea pig large eosinophilic INIB in ductal epi cells of submaxillary salivary gland, can also see in brain, lung, kidney, spleen, pancreas, thymus and liver

A

Cytomegalovirus (Caviid herpesvirus-2)

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45
Q

Severely infected weanling guingea pigs with lethargy, anorexia, watery pasty feces

A

Eimeria caviae (Coccidiosis)

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46
Q

Young guinea pigs <300 g <16 weeks old with WEIGHT LOSS

A

Cryptosporidium wrairi (rarely diarrhea)

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47
Q

Kidney protozoa/coccidia

A

Mouse - Klossiella muris
Guinea pig - Klossiella cobayae

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48
Q

The only helminth host-specific to guinea pigs

A

Parasidodera uncinate (nematode)
Cecal worm
But nonpathogenic

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49
Q

what causes larval migrans in GPs

A

Baylisascaris procyonis (from raccoons)
Migrates to CNS

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50
Q

Tongue worm

A

Linguatula serrata

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51
Q

Lice in guinea pigs

A

Gliricola porcelli (slender, more common)
Gyropus ovalis (ovoid)

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52
Q

Mites in guinea pigs

A

Chirodoscoides caviae - elongated shape, intertwined M/F nymphs, usually subclinical
Trixacarus caviae - burrowing in stratum corneum –> clinical, intensely pruritic –> secondary bacterial infection, zoonotic

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53
Q

Dermatophyte rodents

A

Trichophyton mentagrophytes - zoonotic
GP lesions on muzzle, head, hair, and nails

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54
Q

Enzyme lacking in GPs to convert L-gulonolactone to L-ascarbate and L-dehydroascorbic acid

A

Hepatic enzyme L-gulonolactone oxidase
Vit C important to scavenge free radicals and cross-link collagen –> fragile capillaries (bruising, hemorrhage), prone to infection, painful/swollen joints

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55
Q

How long can diet with stabilized Vit C be stored for?

A

180 days (before it was stabilized, only good for 90 days)

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56
Q

2 types of pregnancy toxemia in GPs

A

Both usually in last 2 weeks
1. Preeclampsia or circulatory form – abnormal vascular changes leading to ischemia of the uteroplacental units –> severe damage on histo
2. Fasting ketosis or metabolic-nutritional form – hypoglycemia and hyperlipidemia –> fatty infiltration

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57
Q

What is sex predilection for barbering in guinea pigs?

A

Inter-male aggression

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58
Q

dystocia in guinea pigs if not bred before…

A

7 months (breed before 6-9 months)

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59
Q

ulcerative pododermatitis in GPs associated with…

A

Staph aureus
Amputation not a tx option

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60
Q

Which antibiotics are associated with typhlocolitis in guinea pigs? And it causes overgrowth of what bacteria?

A

Penicillin, aminopenicillins (amoxicillin, ampicillin), cephalosporins, clindamycin and lincomycin (lincosamides), streptomycin (aminoglycoside) (ones that target gram positive)
C. diff –> cytotoxins A, B

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61
Q

antibiotic that causes otoconial cell loss in inner ear in GP

A

Streptomycin (aminoglycoside)

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62
Q

malocclusion in GPs most often involves

A

premolars and molars (not incisors)

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63
Q

What type of vasculature does guinea pig retina have? This is similar to what other species?

A

paurangiotic like horse (retinal vessels around optic disc)

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64
Q

What are the names and routes of administration for guinea pig allergic skin tests?

A

Buehler test - topical application
Maximization test (Kligman) - intradermal inoculation

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65
Q

similarities in respiratory tract GP and human

A

Anatomically: abundant lung tissue, 3 right/2 left major lobes, well-defined terminal bronchioles, alveoli nearly fully developed at birth, well-innervated trachea

Functionally: airway is quite reactive to certain inhaled compounds, exhibit a cough reflex

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66
Q

how to induce asthma in guinea pig

A

Sensitize airway with repeated IP antigen ovalbumin (OVA) mixed with aluminium hydroxide adjuvant injections, then challenge with OVA via nebulization

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67
Q

how to induce COPD in guinea pigs

A

Induction in GP by exposure to cigarette smoke followed by adenovirus infection

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68
Q

GP repro similarity to human

A

Hemomonochorial placenta like humans (single layer of trophoblast), trophoblast invasion patterns, and uterine vasculature

Best non-NHP model to study hormonal control of parturition (similar progesterone levels as humans in pregnancy)

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69
Q

which type of GP is model of OA?

A

Spontaneous model: Dunkin-Hartley male - degenerative lesions tibial medial stifle start at 3 months and severe by 9 months. Strains 2 and 13 good controls (negligible OA)

induced model: partial medial meniscectomy or injections of sodium mono-iodoacetate

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70
Q

State of cholesterol in which rodent species is low-density lipoprotein like human?

A

guinea pig

71
Q

which rodent species is highly susceptible to HSV-2 (develop genital lesions similar to humans)

A

guinea pig. they also show neurologic effects: urinary retention, hindlimb paralysis, and colonic stasis

72
Q

which rodent species is the preferred model for congenital cytomegalovirus infection?

A

Guinea pig (crosses the placenta)

73
Q

Which types of GPs are models of cytomegalovirus infections and what disease do they exhibit?

A

Hartley GPs (pregnant): virus crosses placenta like in humans

Hartley GPs (non-pregnant): model for mononucleosis (Epstein-Barr, a gamma-herpes)

Strain 2 GPs: highly susceptible. Develop disseminated disease including pneumonia like immunosuppressed human.

74
Q

Which rodent species is highly susceptible to and a model for Lassa hemorrhagic fever virus (Arenavirus)? Which strain is particularly susceptible?

A

Guinea pigs; develop interstitial pneumonia and usually fatal

Strain 13 - mortality 80-100%

75
Q

Which species of rodent is a model of Junin virus (HHS select agent) which causes polioencephalitis, rear limb paralysis followed by death?

A

Guinea pig. Passage through GP increases neurotropism of the virus.

76
Q

Which rodent species is a model of Ebola, specifically the Zaire subtype?

A

Guinea pig. Not lethal; GPs used to study vaccines prior to NHPs

77
Q

Which rodent species is used to evaluate virulence of High pathogenicity influenzas (H5N1 - bird flu and H1N1 - swine flu) and is an alternative to ferret model for transmission studies?

A

Guinea pigs. They develop only modest lethargy and weight loss followed by recovery.

78
Q

Which rodent species is a model of Respiratory Syncytial Virus (RSV, Paramyxoviridae)?

A

Guinea pigs. They develop bronchiolitis and airway hyper-responsiveness after RSV infection. Can also study asthma as a long-term sequela observed in humans after RSV.

79
Q

Are outbred guinea pigs (eg Hartley) or inbred guinea pigs (eg Strain 2, Strain 13) more susceptible to allergic sensitization?

A

Outbred! The inbred ones can be a control in studies involving allergic sensitization.

80
Q

What are the advantages of the guinea pig model of Mycobacterium tuberculosis?

A

GP is historical and current model of TB. Unlike mice, GPs develop caseous cavitary lesions in lungs. Like children, GPs develop necrotizing lymphadenitis of hilar lymph nodes.

81
Q

What is the chamber used to test aerosolized drugs against Mycobacterium tuberculosis in guinea pigs?

A

Madison Aersol Exposure Chamber (ABSL-3!)

82
Q

What is the only animal model of Chlamydia with sexual transmission?

A

Guinea pigs - Chlamydia caviae; mimics human transmission

83
Q

What is the main animal model for Legionnaires’ disease caused by Legionella pneumophila?

A

Guinea pig is a classic model. Infected by aerosol and develop severe pneumonia.

84
Q

Is guinea pig a good model of myocardial infarction by coronary artery occlusion?

A

No; GPs have well-developed collateral coronary artery system making it difficult to produce acute infarcts by coronary artery occlusion

85
Q

While guinea pig pups are precocious, voluntary ____ does not occur until 7-14 days old?

A

Micturition (urination)

86
Q

The diagnostic Quellung reaction is used to detect which agent?

A

Strep pneumoniae (remember that has no Lancefield group –> needs something else!). This involves swelling (visible clearing) around capsule when mixed with antibodies.

87
Q

What is most reliable diagnostic test for guinea pig adenovirus?

A

PCR of lung tissue (no serology test available; also cross reactivity with mouse adenovirus)

88
Q

Which guinea pig virus has cross reactivity with mouse Theilovirus?

A

Poliovirus (both Picornaviridae)

89
Q

Guinea pigs are highly susceptible to an infection associated with high mortality, acute death, reproductive disorders, as well as lung and liver lesions with which bacterial organism?

A

Listeria monocytogenes

90
Q

According to the AWA, the floor space requirement for guinea pigs in the United States is ______ in2 for animals weighing 350 g or less and ______ in2 for animals weighing more than 350 g?

A

60 and 101 respectively

91
Q

According to the AWA, the ambient temperature shall not be allowed to fall below 60°F, nor to exceed 85°F for indoor facilities housing what species?

A

Guinea pigs and hamsters

And hamsters cannot be housed outdoors!

92
Q

What ABSL is appropriate for Mycobacterium tuberculosis studies in mice and guinea pigs?

A

ABSL-2 (ABSL-3 for primates)

93
Q

Which reflex is not a reliable indicator of a surgical plane of anesthesia in a guinea pig (Cavia porcellus)?

A

Pedal withdrawal

94
Q

Older female guinea pig with bilateral flank alopecia likely caused by…

A

Ovarian cysts.
Common in older female
Usually bilateral
May be caused experimentally by androgen/estrogen administration

95
Q

Glycogen accumulation in guinea pig heart most commonly in which part of the heart? What stain is used?

A

Left ventricle. Stain with PAS.

96
Q

Which of the following sites is the preferable location of venipuncture to collect large amounts of blood from a sedated Cavia porcellus?

A

Anterior vena cava

97
Q

To provide regional analgesia to repair a femoral fracture in either a pig or a guinea pig, the local analgesic agent is infiltrated around which nerve(s)?

A

Femoral (sensory to cranial and medial aspects) and sciatic (sensory to caudal aspect)

98
Q

According to AWA, what is required height for enclosures housing guinea pigs, rats, hamsters, rabbits?

A

GPs: 7” (same as rat)
Hamsters: 6”
Rabbits: 16”

99
Q

What is a potential adverse effect of administering Complete Freund’s Adjuvant (CFA)?

A

Granulomas

100
Q

Do rats and mice infected with E. cuniculi typically show clinical signs?

101
Q

Is the Charles River IAF hairless guinea pig, a mutant strain of albino Hartley guinea pigs, immunocompetent or immunocompromised?

A

“Nude” but immunocompetent!

102
Q

Which rodent species gets rhabdomyomas in the heart? What stain to use?

A

Guinea pigs

PAS for glycogen (use alcohol-fixed tissue)

103
Q

Why is Vitamin C critical for collagen formation?

A

It is essential in the hyroxylase reactions necessary for the formation of hydroxyproline and hydroxylysine

104
Q

Metastatic calcification observed in guinea pigs when diet is…

A

Low in Mg, Incorrect Ca:P ratio, or High vitamin D

105
Q

What is the minimum daily maintenance requirement of ascorbic acid in guinea pigs?

A

At least 10 mg/kg per day

106
Q

Foa-Kurloff cells in guinea pigs are the counterpart of which of the following types of cells in other animal species?

107
Q

According to AWA, how many hamsters, rabbits, and guinea pigs can be transported together?

A

15 rabbits
15 guinea pigs
50 hamsters

108
Q

Which rodent species has thymus located outside of the thorax?

A

Guinea pig; located in ventral cervical region

109
Q

What is natural host of LCMV? What are the clinical signs in mice, rats, hamsters, and GPs?

A

Mouse

Minimal clinical signs in mice and rats
More severe in hamster and guinea pig; can see neuro signs

110
Q

What is the major source of allergen in mice, rats, guinea pigs, and rabbits?

A

Mice, rats, guinea pigs - Urine

Rabbits - Fur

111
Q

Which species cannot be housed outdoors according to AWA?

112
Q

Whose approval is needed to house guinea pigs outdoors?

A

The Deputy Administrator of the Animal and Plant Health Inspection Service (APHIS)

113
Q

Scientific name for Mongolian gerbil

A

Meriones unguiculatus

114
Q

Other term that means gerbil

A

Jird (Arabic for gerbil)

115
Q

Meriones unguiculatus use in research

A

Stroke (ligation carotid artery), epilepsy, auditory research (large tympanic bulla), territoriality behavior, protozoa (Giardia lamblia & babesia divergens), nematodes, Hydatid disease: Echinococcus granulosus (larval proliferations and mets) and E. multilocularis., Cysticercosis model as well, Taenia polyacantha, T. crassiceps, T. solium, Digenetic flukes: schistosomiasis, parasitic trematodes (Schistosoma japonicum, S. haematobium, Paragonimus heterotrems, Austrobilharzia variglandis)

Young gerbil: rift valley fever virus w/o extraneural manifestations, arbovirus transmission enhancement by coinfection with microfilariae

116
Q

Ventral abdominal marking gland in gerbils depends on ___ and is ___ in males.

A

Androgen-dependent

Larger in males

Orange-brown, very noticeable under fur

117
Q

Adrenal cortex of gerbil is ___X the size of that of a rat compared to body weight.

118
Q

Gestation for lactating and non-lactating gerbil

A

Non-lactating gestation:24-26d, lactating F gestation: 27d

If post-partum breeding, delayed implantation, gestation may be as long as 48d.

119
Q

T/F: Gerbils pair-bond for life

120
Q

Age at which gerbils eat solid food, stop suckling, and wean

A

Eat solid food: 16d
Suckle: 21d
Wean: 25d

121
Q

Pelleted rodent diet fine for gerbils but will develop high cholesterol if fat >___%.

122
Q

Gerbils develop nasal dermatitis if humidity = ____.

123
Q

What causes sore nose in gerbils?

A

Staph spp mixed with excess Harderian gland secretions (similar to chromodacryorrhea in rats). Stress from enviro RH >50%, overcrowding.

Those with Harderian gland removed do not develop

124
Q

What is the most common fatal disease of gerbils?

A

Tyzzer’s disease (Clostridium piliforme)

125
Q

What causes an acute epidemic in gerbils with colonic hyperplasia?

A

Citrobacter rodentium (similar lesions to Transmissible Murine Colonic Hyperplasia)

126
Q

What causes ulceration, gastritis, intestinal metaplasia, adenocarcinoma in gerbils?

127
Q

What pinworm affects gerbils?

A

Syphacia obvelata (passes between mice and gerbils)

128
Q

What nematode is found in the small intestine of gerbils without clinical signs?

A

Dentostomella translucida

129
Q

What do gerbils develop with standard rodent chow?

A

spontaneous periodontal disease after 6 mos on standard chow.

10% of these became obese w/ impaired glucose tolerance, diabetes and dental caries

130
Q

At what age do gerbils develop seizures? What is prevalence and the cause?

A

2 mos of age-20-40% develop reflex stereotypic epileptiform seizures

Single autosomal locus w/ at least 1 dominant allele, variable penetrance

Response to sensory stimulation. Variable severity with no lasting effects.

Usually better with age, susceptibility in adults of certain lines due to deficiency cerebral glutamine synthetase

131
Q

Treatment for cystic ovaries in gerbil

A

Surgical removal of affected ovary does not impact reproductive performance

132
Q

Two most common neoplastic diseases of gerbils

A

SCC ventral scent gland (M) & ovarian granulosa cell tumors (F) account for over 80% tumors in animals 3+

133
Q

Age-related diseases of gerbils

A

Chronic interstitial nephritis, renal cortical retention cysts, calcinosis cutis, aural cholesteatoma

134
Q

Which rodent has incomplete circle of Willis and used to study stroke?

A

Gerbil (Meriones)

135
Q

In which rodent does Bowman capsule in sexually mature males have lamina muscularis?

A

Gerbil (Meriones)

136
Q

Cage size requirements for gerbils?

A

No cage size requirements per Guide or AWA

137
Q

Which rodent has fatal toxicity from the antibiotic dihydrostreptomycin?

A

Gerbil (Meriones)

(direct neuromuscular blocking by inhibition of Acetylcholine release)

138
Q

How many mammae do hamsters have?

A

7 pairs (mice 5 pairs, rats 6 pairs)

139
Q

Width of opening for hopper for hamsters?

140
Q

How to mate hamsters - bring M to F or vice versa?

A

F very territorial - bring her to male’s cage

141
Q

What dental condition are hamsters a model for?

A

Dental caries

142
Q

What happens if male hamsters are administered estrogen?

A

Renal tumors

143
Q

Most common site of polycystic disease in guinea pigs, hamsters, mice, and rats?

A

Go2 Hell Mark
guinea pigs gerbil ovary
hamsters liver
mouse rat kidney

144
Q

What stain to use for Chlamydia caviae?

A

Giemsa or Macchiavello stains

145
Q

GP with suspected pregnancy toxemia specifically the circulatory form/pre-eclampsia. What do you see in the urine?

A

Acidic pH, ketones, proteinuria

146
Q

Which rodent species does not normally participate in coprophagia if fed a nutritionally complete diet?

A

Meriones unguiculatus (Mongolian gerbil)

147
Q

In which anatomic location are cardiac thrombi most likely found in Mesocricetus auratus?

A

Left atrium

Usually secondary to heart failure

148
Q

Which bedding type would interfere with studies involving vitamin C depletion in Cavia porcellus?

A

Cedar (contains low levels of Vit C)

149
Q

Name predisposing conditions for the development of pregnancy toxemia in guinea pigs during the last trimester

A

MULTIparous
obese
stressed
large fetal load

150
Q

Urolithiasis occurs more often in females over ____ months old and _____ occurs in aged males

A

30 months (2.5 years); urinary tract blockage by proteinaceous plugs

151
Q

What are the 3 limiting amino acids in guinea pigs?

A

arginine, methionine, tryptophan

152
Q

Can rabbits and guinea pigs get Vitamin D deficiency?

A

No

Do not synthesize from food; primarily from sunlight

153
Q

Supplementation with which mineral offsets hyperphosphatemia in guinea pigs (but along with calcium in excess can cause metastatic mineralization)?

154
Q

Diabetes mellitus, resembling type I diabetes in people, is uncommon in guinea pigs except in certain inbred colonies or male GPs of this strain

A

Abyssinian-Hartley

155
Q

Anorexia in guinea pigs is commonly caused by what husbandry changes?

A

Change in feeders, waterers, food

Very neophobic

156
Q

Guinea pigs can become heat stressed at temps above ___F.

157
Q

Which sex of guinea pig does trichotillomania (ingestion of cagemate fur) vs barbering with skin damage?

A

Trichotillomania - females

Barbering/skin damage - males

158
Q

What is the top differential for bilateral, symmetrical hair loss over flanks and rump and reduced reproductive performance in a 2 year old female guinea pig?

A

Cystic rete ovaries

159
Q

T/F Hamsters are altricial, but born with incisors

160
Q

Hamster cheek pouches are rich in ____ cells and lack ____.

A

Mast cells
Lymphatic drainage

161
Q

What do PGAM-1 cell line and nitrosamines cause in hamsters?

A

Pancreatic cancer

162
Q

Myomorpha placenta

A

Labyrinth hemochorial

163
Q

Which species do not have IgD?

A

Hamsters, rabbits

164
Q

What is hamster sensitive and resistant to?

A

Sensitive: steroid, serotonin
Resistant: morphine, histamine, pentobarbital, radiation

165
Q

Hamster should be mated on day ___ after post-ovulatory discharge. Bring the ___ to the ___’s cage.

A

3rd

Bring female to the male cage (females highly territorial and may attack if male comes onto their territory)

166
Q

In hamsters STZ more effective and reliable than alloxan, and adding ___ IP 15 min before STZ partially protects against betatoxic effect of STZ resulting in partial preservation of insulin stores

A

nicotinamide

167
Q

Heritable cardiomyopathy in hamsters is via defect in the ____ gene, component of dystrophin complex

A

sarcoglycan

168
Q

COPD in hamsters induced by 1 intratracheal dose of ___ or ___-deficient diet.

A

porcine pancreatic elastase or feeding copper deficient diet

169
Q

In which rodent is the oocyte penetrable by human sperm and used to assess human fertility using the zona-free ___ oocyte assay?

A

Hamster zona-free oocyte assay (HZFO)

170
Q

Hamsters are highly susceptible to C. diff following tx with which antibiotics?

A

PLACE - Penicillin, Lincomycin, Ampicillin, Clindamycin, Erythromycin

Tetracyclines and metronidazole are OK

171
Q

For Lawsonia in hamsters, weanlings are the most susceptible (3-4 wks), decreased by 6 wks and resistant by ___ weeks of age

172
Q

Non-small cell lung carcinoma can be induced in hamsters by injecting ___.

A

NNK

4-methylnitrosamino-1-3-pyridyl-1-butanone (NNK - Nicotine-derived Nitrosamine Ketone)

173
Q

APA (Albino-Panda-Albino) hamsters develop ___ spontaneously and ___ inducible.

A

Atrial thrombosis

Diabetes with nephropathy w/ STZ

174
Q

T1 diabetes

A

NOD mouse
BB rat
Abyssinian-Hartley GP
Chinese hamster

ACLAM Boards Prep (16 decks)

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