Gota. Flashcards

1
Q

Gota. Hiperuricemia.

A

Ac urico > 6.8mg/dl

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2
Q

Gota. Detonador del dolor

A

Disminucion de su excresion 90%

Sobreproduccion 10%

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3
Q

Gota. Crisis por sobreproduccion.

Hiperuricemia primaria

A

Idiopatica. def de HGFRT, hiperactividad de sintasa de fosforribosilpirofosfato

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4
Q

Gota. Crisis por sobreproduccion.

Hiperuricemia secundaria

A

Sobreingesta de purinas, degradacion acelerada de ATP(etano, intolerancia a la fructosa, hipoxemia, hipoperfusion, ejercicio extenuante, hipertrigliceridemia)

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5
Q

Gota. Crisis por hipoexcresion.

Hiperuricemia primaria

A

Idiopatica, nefropatia hiperuricemica familiar juvenil

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6
Q

Gota. Crisis por hipoexcresion.

Hiperuricemia secundaria

A

Dismunucion en TFG, incremento en la reabsorcion tubular de urato (deshidratacion , diureticos, resistencia a la insulina) inhibicion de la secresion tubular de uratos (acidosis lactica y cetoacidosis)
HAS, enf tiroidea, farmacos

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7
Q

Gota. FR

A

Ingesta alta en carne, marisco y cerveza

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8
Q

Gota. Articulaciones mas fx afectadas

A

Distales u osteoartrosicas

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9
Q

Gota. Tofos

A

Cristales de urato monosodico se depositan en mebrana sinovia, bursas, tendones, riñones

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10
Q

Gota. Manifestacion temprana mas fx

A

Artritis monoarticular aguda nocturna con dolor y edema subitos
Urolitiasis es fx

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11
Q

Gota. Etapas en la enf.

Hiperuricemia asintomatica

A

Etapa 1

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12
Q

Gota. Etapas en la enf.

Artritis gotosa aguda

A

Etapa 2

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13
Q

Gota. Etapas en la enf.

Periodo intercritico

A

Etapa 3

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14
Q

Gota. Etapas en la enf.

Gota tofacea cronica

A

Etapa 4

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15
Q

Gota. Dx

A

Artrocentesis con cristales de urato monosodico

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16
Q

Gota. Tx. Artritis gotosa aguda.

A
Colchicina  + AINE (indometacina, ibuprofeno, diclofenaco)
Dolor persistente (opioide)
17
Q

Gota. Tx. Artritis gotosa aguda refractaria o contraindicaciones de AINES o colchicina

A

Corticoides intraarticulares (triamcinolona o metilprednisolona) u ACTH IM

18
Q

Gota. Tx. Hiperuricemia.

A

Meta terapeutica <6.8
Baja ingesta de purinas y etanol
Inhibidores de la oxidasa de xanitina (alopurinol, de eleccion)
Usar uricosuricos (probenecid, sulfinpirazona, benzobromarona)