GOSH 2 Flashcards
What is the 1st line investigation in post-menopausal bleeding?
TV US to look at endometrial thickness –> pipelle biopsy to sample endometrium (can be used to diagnose endometrial cancer in most cases).
What is the next investigation if a pipelle biopsy has been inconclusive when investigating endometrial cancer?
Hysteroscopy with biopsy
Mx of obstetric cholestasis?
Induction of labour at 37-38 weeks (due to increased risk of stillbirth)
Mx of Factor V Leiden in pregnancy?
LMWH antenatally + 6 weeks postpartum
What can be used in management of endometriosis if NSAIDs/COCP/progestogens have not been effective?
GnRH analogues (pseudo-menopause)
Define premature ovarian failure
The onset of menopausal symptoms and elevated gonadotrophin levels before the age of 40 years.
2x samples of FSH required
Give some causes of oligohydramnios
1) PROM
2) Potter sequence: bilateral renal agenesis + pulmonary hypoplasia
3) IUGR
4) Post-term gestation
5) Pre-eclampsia
In a very athletic woman, what causes 2ary amenorrhoea?
Hypothalamic hypogonadism
Is diabetes a high risk factor for pre-eclampsia?
Yes
Are women with autoimmune conditions such as SLE or antiphospholipid syndrome at high risk of pre-eclampsia?
Yes
What are some normal lab findings in pregnancy?
1) reduced urea
2) reduced creatinine
3) increased urinary protein loss
This is due to increased perfusion to the kidneys in pregnancy.
Is aspirin safe in breastfeeding?
No - risk of Reye’s
How long can a urine pregnancy test remain positive following termination?
Up to 4 weeks
Why is COCP contraindicated 21 days post partum?
Increased VTE risk
What is a history of sudden collapse occurring soon after a rupture of membranes suggestive of?
Amniotic fluid embolism
Next step if suspicion of ovarian cancer but there IS an abdominal or pelvic mass?
CA125 and US test can be bypassed and the patient directly referred to gynaecology
Mx of GBS colonisation in pregnancy?
Intrapartum IV benzylpenicillin
What is the gold standard investigation for mycoplasma genitalium?
NAATs
What are 3 key features of 3ary syphilis?
1) Neurosyphilis e.g. labile mood, confusion, delusions, seizures, judgement impairment
2) Aortic aneurysms
3) Gummatous lesions
What is Argyll-Robertson pupil? What is it found in?
A specific finding in neurosyphilis.
It is a CONSTRICTED pupil that accomodates when focusing on a neear objct but does not react to light.
What can increase the risk of genital wart recurrence?
Smoking
1st line management of uncomplicated Mycoplasma genitalium?
Doxycycline for 7 days
Followed by azithromycin for 2 days
Management of complicated Mycoplasma genitalium?
Moxifloxacin 400mg daily for 14 days
What is the protein on the surface of HIV that binds to CD4+?
gp120
What is PrEP a combination of?
2x NRTIs
Emtricitabine + tenofovir disoproxil
Which form of contraception can increase the risk of BV?
Copper IUD
What criteria can be used for the diagnosis of BV?
Amsel criteria
What makes up the Amsel criteria? (4)
1) Homogenous discharge on examination
2) Microscopy showing ‘clue cells’
3) Vaginal pH >4.5
4) Fishy odour on adding 10% potassium hydroxide to vaginal fluid
Describe the ‘whiff test’
Presence of an amine odour when POTASSIUM HYDROXIDE is added to vaginal fluid.
What does a positive Whiff test indicate?
BV
What are the main component of the healthy vaginal bacterial flora?
Lactobacilli
Which form of contraception may be PROTECTIVE against BV?
COCP
What criteria can be used to grade the appearance of vaginal flora?
Hay/Ison Criteria
What are the 4 gradings of the Hay/Ison Criteria?
Grade I (normal) –> Lactobacilli predominate
Grade II (intermediate) –> Mixed flora with some lactobacilli but Gardnerella or Mobiluncus also present
Grade III (BV) –> Predominantly Gardnerella and/or Mobiluncus. Few or absent lactobacilli.
Grave IV –> Gram-positive bacteria predominate
What does the Hay/Ison criteria take into account?
The microscopic appearance of gram-stained vaginal smear.
What 2 criteria can be used in the diagnosis of BV?
1) Hay/Ison criteria
2) Amsel criteria
How many of the Amsel criteria must be met to diagnose BV?
3/4
What are 3 possible investigations in BV?
1) Whiff test
2) Vaginal pH test (using swab & pH paper)
3) Charcoal vaginal swab
What is a key complication of BV?
At higher risk of acquiring and transmitting STIs.
What is the main complication of BV during pregnancy?
1st trimester miscarriage
How do lactobacili keep the vaginal pH low?
By producing lactic acid
What investigation can confirm the diagnosis of candidiasis?
Charcoal swab
Are routine investigations are not typically required for acute, uncomplicated vulvovaginal candidiasis cases?
No
Medical treatment is recommended for certain groups of individuals with BV.
What are these groups?
1) Anyone with symptoms
2) Any pregnant individuals (regardless of choice in continuation of pregnancy)
What defines recurrent vulvovaginal candidiasis?
≥4 episodes in 1 year
With at least 2 episodes confirmed by microscopy or culture when symptomatic.
What are ‘clue cells’?
Epithelial cells from cervix with bacteria stuck inside (typically Gardnerella vaginalis).
Key contraindication of oral antifungal tablets (e.g. fluconazole) for candidiasis?
pregnancy & breastfeeding
Increased levels of which hormone can increase the risk of candidiasis?
Oestrogen e.g. higher in pregnancy
Lower after menopause so risk is lower
When are antibiotics started in PID?
Empirically
Give 4 risk factors for candidiasis
1) Immunosuppression e.g. steroids, HIV
2) Higher oestrogen e.g. pregnancy
3) Poorly controlled diabetes
4) Broad spectrum Abx
What is Fitz-Hugh-Curtis Syndrome?
A complication of PID.
It is caused by inflammation and infection of the liver capsule (Glisson’s capsule), leading to adhesions between the liver and peritoneum. Bacteria may spread from the pelvis via the peritoneal cavity, lymphatic system or blood.
How long are symptoms present for in bladder pain syndrome (AKA interstitial cystitis)?
> 6 weeks
What organs of the pelvis are affected in PID?
Endometritis –> endometrium
Salpingitis –> fallopian tubes
Parametritis –> parametrium
Oophoritis –> ovaries
Peritonitis –> peritoneal membrane
Typical outpatient Abx regime in PID?
1) Single IM dose of ceftriazone
2) Oral doxycyline 14 days (to cover chlamydia & mycoplasma genitalium)
3) Oral metronidazole 14 days (to cover anaerobes e.g. Gardnerella)
What should you always look for signs of in PID?
SEPSIS
In which cases of PID require admission for IV Abx? (2)
1) Sepsis
2) Pregnancy
What can be seen during cytoscopy in interstitial nephritis (in approx 20% of patients)?
1) Hunner lesions –> red, inflamed patches of the bladder mucosa associated with small blood vessels
2) Granulations –> tiny haemorrhages on the bladder wall
What is hydrodistension?
Purpose of it in interstitial nephritis?
Filling the bladder with water, to high pressure, during cystoscopy (requires GA).
This can give a temporary (3-6 month) improvement in symptoms.
PID can less commonly be caused by non-STIs, such as what?
(3)
1) Gardnerella vaginalis
2) H. influenzae
3) E. coli
Complications of PID?
1) Sepsis
2) Abscess
3) Infertility
4) Increased risk of ectopic
5) Fitz-Hugh-Curtis syndrome
6) Chronic pelvic pain
In patients presenting with urinary incontinence, what is it important to rule out? (2)
1) UTI
2) Diabetes
Get urinalysis
What age prematurity does retinopathy of prematurity affect?
<32 weeks gestation
What steroid is used to educe the chance of RDS in PROM?
Dexamethasone
What investigations may be required in recurrent candidiasis?
1) check compliance with previous treatment
2) confirm diagnosis: high vaginal swab (charcoal) for microscopy and culture
3) blood glucose test/HbA1c to exclude diabetes
4) exclude differential diagnoses such as lichen sclerosus
Are progestogen-only methods of contraception safe to use alongside sequential HRT?
Yes
What is the classic triad of vasa praevia?
1) Rupture of membranes
2) Painless vaginal bleeding
3) Foetal bradycardia
Maternal risk in vasa praevia vs placenta praevia?
Vasa praevia - no major maternal risk
Placenta praevia - materanl risk
Typical features of hydatidiform mole?
- May have bleeding in 1st or early 2nd trimester
- Associated with exaggerated symptoms of pregnancy e.g. hyperemesis.
- Uterus may be large for dates
- Serum hCG is very high
What Bishop’s score indicates that the cervix is ripe, or ‘favourable’?
≥8
What intervention should be performed in a Bishop’s score ≥8?
No interventions required
There is a high chance of spontaneous labour.
What does a Bishop’s score <5 indicate?
Indicates that labour is unlikely to progress without induction.
What is the preferred method of induction in a Bishop’s score <5?
Vaginal prostaglandin E2
What is the preferred method of induction in a Bishop’s score >6?
Amniotomy & IV oxytocin infusion
Describe the Bishop’s score
Cervical position:
- posterior (0)
- intermediate (1)
- anterior (2)
Cervical dilation:
- <1cm (0)
- 1-2cm (1)
- 3-4cm (2)
- >5cm (3)
Cervical consistency:
- firm (0)
- intermediate (1)
- soft (2)
Cervical effacement:
- 0-30% (0)
- 40-50% (1)
- 60-70% (2)
- 80% (3)
Foetal station:
- -3 (0)
- -2 (1)
- -1, 0 (2)
- +1, +2 (3)
What is the 1st line management of N&V in pregnancy/hyperemesis gravidarum?
Antihistamines e.g. oral cyclizine or promethazine
What is the 2nd line management of N&V in pregnancy/hyperemesis gravidarum?
1) Oral ondansetron
2) Oral metoclopramide or domperidone