Glucose control Flashcards
1
Q
Why can’t glucose pass into cells easily?
A
Very polar - there are lots of OH groups in periphery
2
Q
What happens when there is excess glucose?
A
Glycolysis converts to pyruvate
Pyruvate to aCOA
aCOA can enter kerb’s to produce ATP
aCOA is also converted by B oxidation to form FFA
FFA form ketones
Ketones form ketone bodies which dissociate H+ to form acidosis
3
Q
How is insulin released when glucose is high?
A
Inside B cell, endoplasmic reticulum packages insulin into vesicles where high conc causes crystallisation
This is released by exocytosis when glucose is high
4
Q
What happens when glucose binds to GLUT 2?
A
ATP -> ADP
K+/ATPase channels close
PM depolarisation
Ca2+ influx causes insulin release
