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BIOCHEM ✨ > GLUCONEOGENESIS > Flashcards

GLUCONEOGENESIS Flashcards

0
Q

3 precursors or non carbohydrate sources so glucose could be produced

A

Lactate
Amino acids
Glycerol

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1
Q

Gluconeogenesis occurs in the

A

Liver
Kidneys
Skeletal and heart muscle

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2
Q

Gluconeogenesis utilizes 2 compartments of the cell

A

Mitochondrion

Cytosol

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3
Q

Hormones responsive to decrease blood glucose

A

Glucagon and epinephrine

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4
Q

Hormone that:
stimulates glycolysis
inhibits gluconeogenesis

A

Insulin

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5
Q

Hormone that:
Stimulates: gluconeogenesis
Inhibits: glycolysis

A

Glucagon

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6
Q

Step 1 in gluconeogenesis

Enzyme:

A

Conversion of pyruvate to Phosphoenolpyruvate

Enzyme: pyruvate carboxylase

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7
Q

Step1
Bicarbonate + pyruvate =
Enzyme:
Vitamin derived Cofactor:

A

Oxaloacetate
E: pyruvate carboxylase
Co: biotin

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8
Q

Step 1
Oxaloacetate + GTP =
Enzyme:

A

Phosphoenolpyruvate

PEP carboxykinase

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9
Q

Type of rxn in step 1 of gluconeogenesis

A

Anaplerotic, anabolic and atp dependent rxn

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10
Q

End product of
Aerobic glycolysis:
Anaerobic glycolysis:

A

Aero: pyruvate
Anaero: lactate

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11
Q

Aerobic glycolysis

Pyruvate ➡️ oxaloacetate ➡️ ____ ➡️ oxaloacetate ➡️ PEP

A

Malate (goes out and reconverted to oxaloacetate)

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12
Q

Anaerobic glycolysis

Lactate ➡️ (cytosol) _____ ➡️ (enters mitochondrion) ➡️ oxaloacetate (no need to go out) ➡️ PEP

A

Pyruvate

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13
Q

Step 2 in gluconeogenesis:

Enzymes:

A

Conversion of PEP ➡️ F 1,6 BP ➡️ F 6 P

Fructose 1,6 bisphosphatase & phosphoglucose isomerase

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14
Q

Reverse reaction in glycolysis
Reversible
Isomerization

A

Step II of gluconeogenesis

Con of PEP ➡️ F16BP➡️F6P

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15
Q

Step III:
Enzyme:
Occurs in:

A

Conversion of G-6-P ➡️ Glucose
G-6-phosphatase
Endoplasmic reticulum

16
Q

regulatory enzymes in GLUCONEOGENESIS

A 
Pyruvate dehydrogenase
Pyruvate carboxylase
PEPCK
Pyruvate kinase
PFK1
F 1,6 biphosphate
Glucokinase
17
Q

How many atp formed in gluconeogenesis?

A

None

18
Q

Areas if gluconeogenesis in BRAIN

A

Cytosol

Mitochondrion

19
Q

Areas if gluconeogenesis in LIVER

A

Cytosol
Mitochondrion
ER

BIOCHEM ✨ (12 decks)

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