Gluconeogenesis Flashcards

1
Q

Principales substratos

A

Aminoácidos, glucogenicos, lactato y glicerol

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2
Q

Substrato inicial

A

Lactato, propionato, glicerol, aminoácidos glucogenicos

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3
Q

Compartimento celular

A

Citosol y membrana

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4
Q

Primer paso

A

Piruvato —-> oxalacetato

Irreversible
Actúa piruvato carboxilasa
ATP a ADP

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5
Q

Segundo paso

A

Oxalacetato —-> fosfoenol piruvato

Irreversible
Actúa PEP carboxiquinasa
Saca GDP y CO2

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6
Q

Tercer paso

A

Fosfoenolpiruvato (2) —> 2-fosfoglicerato (2)

Actúa enolasa

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7
Q

Cuarto paso

A

2 fosfoglicerato x2 a 3-fosfoglicerato x2

Actúa fosfoglicerato mutasa

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8
Q

Quinto paso

A

3 fosfoglicerato x2 a 1,3 bifosfoglicerato

Actúa fosfoglicerato cinasa

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9
Q

Sexto paso

A

1,3- bifosfoglicerato a gliceraldehido 3-fosfato

Actúa Gliceraldehido fosfato deshidrogenasa

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10
Q

Septimo paso

A

Glicerato 3-fosfato a Dihidroxiacetona fosfato

Actúa Triosa fosfata isomerasa

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11
Q

Octavo paso (ya no son dos, ok)

A

Dihidroxiacetona fosfato a fructosa 1,6-bifosfato

Actúa aldolasa

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12
Q

Noveno paso

A

Fructosa 1,6-bifosfato a fructosa-6-fosfato

Actúa fructosa 1,6- bifosfatasa

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13
Q

Décimo paso

A

Fructosa 6 fosfato a glucosa 6 fosfato

Actúa fosfohexosa isomerasa

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14
Q

Glucosa 6-fosfato a glucosa

A

Porrrr glucosa 6 fosfatasa

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15
Q

Diferencia en las enzimas de glucolisis y Gluconeogenesis

A

Glucolisis: de glucosa a glucosa 6 fosfato se ocupa HEXOCINASA
Gluconeogenesis: de glucosa 6 fosfato a glucosa se ocupa GLUCOSA 6 FOSFATASA

Glucolisis: de fosfoenol piruvato a piruvato se ocupa PIRUVATO CINASA
Gluconeogenesis: de piruvato a oxalacetato se ocupa PIRUVATO CARBOXILASA para pasar fosfoenolpiruvato

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