Glucocorticoids, mineralcorticoids, and adrenocortical antagonists Flashcards
Corticosteroids are usually grouped according to what 3 major actions?
Effects of carbohydrate metabolism (glycogen deposition, and gluconeogenesis) Anti-inflammatory effects, relative potencies in Na retention
How long between the time you give corticosteroids and manifestation of effects?
several hours for genetic stuff. There are some immediate responses
Aldosterone and cortisol both bind to the ____ receptor with equal affinity
mineralcoritcoid
Which is present in higher levels in circulation, cortisol or aldosterone?
Cortisol
What does 11B hydroxysteroid dehydrogenase type 2 do?
converts cortisol to cortisone in certain cells of the kidney, colon, and salivary glands
Does cortisone bind to the mineralcorticoid receptor?
NO
How do GC protect the brain during starvation?
keeping blood glucose elevated by increased gluconeogenesis and glycogenolysis in liver
What do GC do in peripheral tissues?
decrease glucose utilization, increase proteolysis, activate lipolysis
All the effects of GC _____insulin. Why is this important?
oppose- can be a major problem in diabetic pts
What are the 2 major effects of GC on lipid metabolism?
redistribution of fate, permissive effects on other agents such as GH and B adrenergic receptor agonists in increasing lipolysis in adipose tissue
____ is the most important MC.
Aldosterone
What is the overall affect of aldosterone?
increased ECFV, hypokalemia, alkalosis
What does aldosterone deficiency cause?
Na loss, decreased extracellular fluid, hyponatremia, hyerkalemia, acidosis
What are the affects on CV?
From MC actions–> increase in Na retention–> HTN
Enhance vascular reactivity
