Glucocorticoid Flashcards
1
Q
Names
A
Hydrocortisone Prednisone Triamcinolone Dexamethasone Beclomethasone
2
Q
MOA
A
decrease production of leukotrienes and prostagladins by inhibiting phospholipase A2 and expression of COX2
3
Q
Use
A
Addisons
Inflammation
Immunosuppression
Asthma
4
Q
Toxicity
A
Iatrogenic Cushing’s syndrome: buffalo hump, moon facies, truncal obesity, muscle wasting, thin skin, bruisability, osteoporosis, adrenocortical atrophy, peptic ulcer, diabetics (if chronic)
Adrenal insufficiency when stopped abruptly after chronic use.
