Cortisol

Question 1

Secreted by

Answer 1

Adrenal zona fasciulata

Question 2

Bound to

Answer 2

Corticosteroid-binding globulin (CBG)

Question 3

Function

Answer 3

1) maintains BP (regulate alpha 1 on aterioles, more sensitive to NE and EPI)
2) reduce Bone formation
3) anti Inflammatory
4) Insulin resistance
5) Gluconeogenesis, lipolysis, proteolysis
6) inhibits fibroblasts (this causes striae)

“Cortisol is BBIIG”

Question 4

Antiinflamm response by cortisol

Answer 4

1) inhibit production of leukotriene and prostagladins
2) inhibit leukocyte adhesion (neutrophilia)
3) blocks histamine release from mast cells
4) reduce eosinophils
5) blocks IL2 production

Question 5

Regulation

Answer 5

CRH (hypothalamus) stimualates ACTH release (ant pit),
causing cortisol production in adrenal zona fasciculata.

Chronic stress indues prolonged secretion

Question 6

Excess cortisol affects regulation by

Answer 6

Decreases CRH, ACTH, and cortisol secretion