Carcinoid syndrome Flashcards
1
Q
Cause
A
From metastatic small bowel tumors,
secreting high levels of serotonin (5-HT)
Most common tumor of appendix
(not seen if tumor limited to GI, since first pass by liver)
2
Q
Symptoms
A
Diarrhea
Cutaneous flushing
Asthmatic wheezing
Right sided valvular disease (endocardial thickening)
3
Q
Lab
A
Increase 5-HIAA in urine Niacin deficiency (because its precursor tryptophan converted to serotonin)
4
Q
Treatment
A
Somatostatin analog (ocreotide)
5
Q
Rule of 1/3
A
1/3 met
1/3 present with 2nd malignancy
1/3 multiple
