Glomerular Filtration and Tubular Reabsorption Flashcards
Why are large, negatively charged molecules not very permeable to the glomerular capillary
they get repelled, not normally filtered
What forces favor filtration
capillary hydrostatic pressure
oncotic pressure in bowman’s capsule
What forces oppose filtration
capillary oncotic pressure
hydrostatic pressure in bowman’s capsul
how do you calculate filtration fraction (FF)
GFR/Renal plasma flow
What happens if FF is increased
oncotic pressure at the efferent end of the glomerular capillaries increases above normal
transcytosis
movement of a substance via couples endocytosis and exocytosis
what is the result of transcytosis
movement of protein into or out of the tubular lumen
peptide hormones, small proteins, and small amts of large proteins are filtered where
at the glomerulus
where are peptides and proteins reabsorbed
in the proximal tubule cells
what happens to proteins after they bind to receptors on the luminal membrane
taken into the cell by endocytosis, where they are digested into amino acids
what happens to the amino acids
transported by carrier proteins through the basolateral membrane
where does ultrafiltrate take place
border between blood and and filtrate
how is sodium reabsorbed
goes down it’s gradient into proximal tubule, Na-H antiporter moves Na out of lumen.
How is glucose reabsorbed
leaves proximal tubule by faciliated diffusion
reabsorpution of solute into interstitum creates ____ which draws ___ out of proximal tubule
osmotic gradient
water
