Acid/Base Regulation Flashcards
how does the kidney respond to alkalosis
excreting alkaline urine
how does the kidney respond to acidosis
excreting acidic urine
what happens to buffer if conc of H+ increases
increases amount of H+ binds to buffer as long as buffer is avaiable
What happens to buffer if conc of H+ decreases
H+ is released from teh buffer thus increasing H+
What is the most important buffer system in the ECF
bicarb
What buffer systme is improtant in buffering urine and ICF
phosphate
what is the protein buffering system important in
buffering agents in blood
where is the ammonia buffer system most useful in
proximal tubule of kidney
desribe the phosphate buffering in respiratory acidosis
Secreted H+ binds to available phosphate (NaHPO4-) and is excreted.
describe bicarb buffering system
- fluid in lumen contains bicarb that was filtered at glomerulus
- H+ joins with bicarb in lumen, makes Co2 and H2O
- CO2 diffuses into renal tubule cell, combines with water to make more H2CO3, which breaks back down into H+ and HCO3-
- bicarb moves down conc gradient across basolateral membrane via carrier mediated diffusion
For every H+ secreted into the tubular lumen what enters the blodo
a bicarbonate ion
when would you be using the glutamine-NH4+ buffering system?
severe respiratory acidosis
Describe the glutamine-NH4 buffering system
in proximal tubule glutamine is metabolized to bicarb which is added to the blood and ammonium ion, NH4+ which is excreted in the urine
hypoventilation is an example of
uncompensated resp. acidosis
hyperventilation is an example of
uncompensated resp. alkalosis
