GI - Physiology - Barrier Function; Swallowing & Gastric Emptying; Motility; Saliva; Gastric Glands Flashcards
What are the three main functions of the GI tract?
Digestion
Absorption
Excretion
What are the names for the three cell layers of the esophagus?
Functional;
prickle;
basal
What two layers protect the gastric epithelium from acidic conditions?
The mucosal layer (superficial) and unstirred water (deep) layers
Does the esophagus have a mucus or unstirred water barrier?
Neither
(only a small amount of bicarbonate from swallowed saliva)
If the mucus and unstirred water layers are depleted, how can gastric epithelium protect itself against stomach acid?
H+ entry into the cell via cation channels is blocked via pH regulation of these channels
True/False.
Some H+ can slip past the tight junctions binding gastric epithelium.
True.
(This will be buffered by the bicarbonate-rich interstitium.)
What are the three buffers to counteract acidity within the gastric epithelium?
Proteins;
bicarbonate;
phosphate
Describe the cell and interstitial acidifier(s) of the gastric epithelium.
Describe the cell alkalinizer(s) of the gastric epithelium basolateral membranes.
The pH of what compartment will determine the intracellular pH of gastric epithelia?
The interstitial pH
(i.e. if the interestitial pH falls, the basolateral epithelial transporters cause a fall in pH in the cells.)
What is the stomach pH at rest?
What is the stomach pH when eating?
~3
1 - 2
What is the stomach alkaline tide?
Parietal cells producing HCl also produce intracellular HCO3-;
this HCO3- then travels through the bloodstream to the surface epithelial cells to contribute to the surface mucosal protection
(A rise in acid leads to a rise in base)
If the epithelium of the esophagus, stomach, or duodenum is damaged and the basement membrane is intact, how long will healing take?
If the epithelium of the esophagus, stomach, or duodenum is damaged and the basement membrane is destroyed, how long will healing take?
30 - 60 minutes (restitution by migration of adjacent cells);
days/weeks/months (regeneration)
What are the two main types of repair for the esophagus, stomach, and/or duodenum?
Restitution (rapid migration of adjacent cells to cover injury);
regeneration (reparative mechanisms; new synthesis of proteins/basement membrane/cells)
True/False.
The mucosal/unstirred water layers in the stomach can entrap damaged epithelial and connective tissue contents, creating an extra buffering layer over ulcerations and damage.
True.
Which prostaglandin is protective for the gastric mucosa?
Which enzyme produces it?
PGE2;
COX-1
What are the effects of PGE2 on the gastric mucosa?
Increased mucus/HCO3- secretion;
increased blood flow;
promotes epithelial restitution
How do NSAIDs cause gastric upset?
By inhibiting PGE2 production by COX-1
COX-__ produces __, which has protective/regenerative effects on the gastric mucosa.
1;
PGE2
Do VIOXX or Celebrex cause gastric upset?
Why or why not?
Should they be prescribed for every day aches and pains?
No;
it only blocks COX-2 (leaving PGE2 production uninhibited);
no –> only blocking COX-2 leads to excess thromboxane production by COX-1
Barrett’s esophagus is a metaplasia of __________ epithelium to _________ epithelium in the ___________.
Stratified squamous,
simple columnar;
esophagus
What is a major risk of Barrett’s esophagus?
Adenocarcinoma development
What are the two main layers of the muscularis externa?
What lies between them?
The inner circumferential layer and the outer longitudinal layer;
the myenteric (Auerbach’s) plexus + connective tissue
Which layer of the muscularis externa is more responsible for GI tract shortening and which is more responsible for peristalsis?
Shortening - longitudinal layer;
peristalsis - circular layer
Which small intestine plexus is sensory?
Which is motor?
Meissner’s (submucosal);
Auerbach’s (myenteric)
What are the two main substances controlling muscle contraction in the gut?
(What does each do?)
Acetylcholine (activation);
nitric oxide (relaxation)
How long does it typically take a bolus to travel down the esophagus?
And the stomach?
And the small intestine?
And the large intestine?
7 seconds;
3 - 4 hours;
2 - 3 hours;
2 - 3 days
What are the three phases of swallowing?
Which are voluntary?
Oral (voluntary),
pharyngeal (medulla control),
esophageal (medulla control)
What happens during the muscular contractions of the pharyngeal phase of swallowing?
Soft palate closure of the nasopharyngeal isthmus;
epiglottis closure of the larnyx
Via what nerve does the medullary swallowing center control pharyngeal and esophageal function?
The Vagus n.
What substance mediates cardiac sphincter relaxation in the lower esophagus?
Nitric oxide
What are the three nuclei of the medullary swallowing center?
Nucleus solitarius (sensory);
nucleus ambiguus (skeletal muscle);
nucleus dorsal motor (smooth muscle)
What is the state of the lower esophageal sphincter when one is not swallowing (i.e. ‘at rest’)?
Constricted
(smooth muscle locking mechanism)
Why is the lower esophageal sphincter necessary under normal conditions?
Gastric pressures (positive abdominal p.) are higher than esophageal pressures (negative intrathoracic p.)
What is secondary peristalsis?
Stretch reflex for the stuck bolus (that wasn’t successfully moved by the primary peristalsis)
Primary esophageal peristalsis is caused by:
Secondary esophageal peristalsis is caused by:
Swallowing;
esophageal distention (stuck bolus)
For what purpose does the lower esophageal sphincter naturally relax in a transient manner?
Due to gastric distention to allow for gas release
(belch reflex)
Where does swallowed food initially collect?
The gastric fundus
What portion of the stomach has the pacemaker zone?
What is its basal electrical rhythym?
The upper body (corpus);
3 waves / min
What part of the stomach is the ‘storage’ portion immediately after eating?
Via what mechanism?
The fundus;
receptive relaxation
Gastrin secretion increases following _________ distention.
Antral (of the gastric antrum)
Distention of the gastric antrum causes an increase in __________ secretion.
Gastrin
What size particles does the pyloric junction allow through to the duodenum?
≤ 2 mm
What is the purpose of enterochromaffin cells in the duodenum?
To regulate the chyme entering the duodenum
(via secretin, cholecystokinin, and the vagovagal reflex)
Low pH in the duodenum is sensed by ____________ cells and ____________ is released.
Enterochromaffin;
secretin
High osmolality in the duodenum is sensed by ____________ cells and the ____________ is activated.
Enterochromaffin;
vagovagal reflex
High fat content in the duodenum is sensed by ____________ cells and ____________ is released.
Enterochromaffin;
cholecystokinin
What effect do each of the following, respectively, have on gastric emptying?
Secretin
The vagovagal reflex
Cholecystokinin
Decrease
Decrease
Decrease
What are secretin’s effects?
To neutralize acidity in the duodenum
- increased pancreatic HCO3- secretion
- increased Brunner’s glands secretion
- decreased gastric emptying
What are cholecystokinin’s effects?
To optimize digestion (especially of fat)
- increased pancreatic enzyme secretion
- increased gallbladder contraction
- decreased gastric emptying
True/False.
The larynx depresses during deglutition.
False.
The larynx rises during deglutition.
Where is calcium absorbed in the small intestine?
Where is iron absorbed in the small intestine?
Where is vitamin B12 absorbed in the small intestine?
Where are bile salts absorbed in the small intestine?
The duodenum and proximal jejunum;
the duodenum and proximal jejunum;
the terminal ileum;
the terminal ileum
What substance(s) is(are) absorbed in the terminal ileum?
Vitamin B12;
bile salts
True/False.
Segmentation waves help push boluses down the small intestine in the process of peristalsis.
False.
Segmentation waves push chyme in both directions, mixing and churning it.
What is the basal electrical rhythym in the duodenum?
What is the basal electrical rhythym in the jejunum?
What is the basal electrical rhythym in the ileum?
12 waves / min
10 waves / min
8 waves / min
______________ causes smooth muscle contraction in the gut.
______________ causes smooth muscle relaxation in the gut.
Acetylcholine;
nitric oxide
What is the ileo-colic reflex?
Upon gastric distention, the ileum empties its content into the colon to make room for incoming material
When the colonic smooth muscle contracts, the ileocecal valve is ____________.
When the ileal smooth muscle contracts, the ileocecal valve is ____________.
Closed (acetylcholine);
open (nitric oxide)