GI Motility - Newer Pro Kinetic Agents

Question 1

Which are the newer Pro Kinetic Agents?

Answer 1

• Lubiprostone (Amitiza)

- Linaclotide (Linzess)

Question 2

Which prostaglandin E1 derivative, bicyclic fatty acid is used for the treatment of chronic idiopathic constipation?

Answer 2

Lubiprostone (Amitiza)

Question 3

How does lubiprostone work?

Answer 3

By increasing intestinal fluid by activating the opening of specific chloride channels on the luminal cells of the intestine. It does not alter serum electrolyte concentrations or produce tolerance like certain laxatives

Question 4

Which guanylate cyclase-C receptor agonist is approved for the oral treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation?

Answer 4

Linaclotide (Linzess)

Question 5

Which peptide can surprisingly be used orally?

Answer 5

Linaclotide (Linzess)

Question 6

What is the black box warning on Linaclotide (Linzess)?

Answer 6

It should not be used in patients younger than 18 years old because of deaths during studies in young mice. It is also a category C risk (risk cannot be ruled out) for pregnancy