Adrenal Steroids - Therapeutically Useful Adrenocorticoids

Question 1

What is the biggest use of chemically modified cortisol molecules?

Answer 1

Treatment of immune diseases

Question 2

What is the method of action of chemically modified cortisol molecules?

Answer 2

Increases glucocorticoid and/or mineralocorticoid potency and duration of action of the steroid = increased anti inflammatory activity

Question 3

Which are the short duration of action (<12 hours) corticosteroids?

Answer 3

• Cortisol (Hydrocortisone)
• Cortisone
• Beclamethasone

Question 4

Which are the intermediate duration of action (12-36 hours) corticosteroids?

Answer 4

• Prednisone
• Methylprednisolone
• Triamcinolone

Question 5

Which are the long duration of action (>48 hours) corticosteroids?

Answer 5

• Paramethasone
• Dexamethasone
• Betamethasone

Question 6

Which corticosteroids have no Mineralocorticoid potency?

Answer 6

The ones with a 16 before the alpha or beta:

• Methylprednisolone
• Triamcinolone
• Paramethasone
• Dexamethasone
• Betamethasone

Question 7

What is Fludrocortisone used for?

Answer 7

Replacement therapy when you are not making Aldosterone (Addison’s Disease). It is used only for mineralocorticoid activity.