Adrenal Steroids - Adrenal Androgens

Question 1

Which is more active, DHEA or testosterone?

Answer 1

Testosterone. DHEA is only 20% as active as testosterone

Question 2

What is the source of the androgens in post menopausal women that gets aromatized by aromatase?

Answer 2

DHEA

Question 3

What causes masculinization of females and precocious development in males?

Answer 3

DHEA

Question 4

What causes angiotensinogen to be released which eventually leads to aldosterone secretion and raising of blood pressure?

Answer 4

• Decreased BP
• Decreased Volume
• Decreased Sodium

Question 5

How does ACTH influence aldosterone during stress?

Answer 5

Causes small increases of Aldosterone

Question 6

What inhibits activity of the zona glomerulosa?

Answer 6

ANP (Atrial natriuretic peptide)

Question 7

What are the steps in the synthesis of Mineralocorticoids?

Answer 7

Deoxycorticosterone (DOC) –> (through 11betaHydroxylase) Corticosterone (steps 1-5) –> 18Hydrocorticosterone (through Aldosterone Synthase II step 6) –> Aldosterone (through Aldosterone Synthase step 7)