GI: Gastric Secretions Flashcards

1
Q

Parietal cells (oxyntic) secrete?

A
Gastric Acid (HCL)
Intrinsic Factor (IF)
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2
Q

Chief cells secrete?

A

Pepsinogen

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3
Q

Mucous cells secrete?

A

Mucus

Bicarbonate (HCO3-)

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4
Q

G cells secrete?

A

Gastrin

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5
Q

Cells of the Body and Fundus?

A
Parietal cells (HCl, IF)
Chief cells (Pepsinogen)
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6
Q

Cells of the Entire Stomach (particularly Antrum)?

A

Mucus cells (Mucus, Bicarbonate)

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7
Q

Cells of the Antrum and Duodenum?

A

G cells (Gastrin)

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8
Q

What does Gastric Acid (HCl) do?

A

Aids in digestion
Activates Pepsinogen into Pepsin
Kills pathogens

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9
Q

What does Intrinsic factor (IF) do?

A

Binds to Vit. B12

–> Leads to its uptake in the Ileum

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10
Q

What does Pepsinogen do?

A

Zymogen for Pepsin

Digests protein at a pH (1.0 - 3.0)

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11
Q

What does Mucus do?

A

Protects Mucosa from Acidic environment and Pepsin

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12
Q

What does Bicarbonate (HCO3-) do?

A

Neutralizes acid

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13
Q

What does Gastrin do?

A

Increases secretion of H+, Pepsinogen, Histamine
Trophic on Gastric mucosa
Increases Gastric motility

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14
Q

What regulates Gastric Acid (HCl)?

A

Stimulus: Gastrin, ACh (Vagus), Histamine
Inhibits: Low pH, Prostaglandins, GIP secretion ( - fb), Somatostatin

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15
Q

What regulates Intrinsic Factor (IF)?

A

Stimulus: Gastrin, ACh (Vagus), Histamine
Inhibits: Low pH, Prostaglandins, GIP secretion ( - fb), Somatostatin

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16
Q

What regulates Pepsinogen?

A

Stimulus: ACh (Vagus), Increased local H+
Inhibits: Somatostatin

17
Q

What regulates Mucus?

A

Stimulus: ACh (Vagus)
Inhibits: None

18
Q

What regulates Bicarbonate (HCO3-)?

A

Stimulus: ACh (Vagus)
Inhibits: None

19
Q

What regulates Gastrin?

A

Stimulus: Small peptides, Amino acids, Ca++ in gastric lumen, GRP (Vagus), Gastric distention
Inhibits: Increase H+ in the Gastric antrum