genetics

Question 1

what % of the population is diagnosed with schizophrenia?

Answer 1

1%

Question 2

what % of people are diagnosed with first degree relative who has the disorder get it also?

Answer 2

10%

Question 3

what % of people with a second degree relative with the disorder also gets it?

Answer 3

2-6%

Question 4

what is the Gene which can cause increased chance of schizophrenia if missing?

Answer 4

22q11 depletion, can increase the chance of getting schizophrenia. 18% of people without 22q11, have schizophrenia which is higher than in relation to 1% population.

Question 5

what type of genetic variation may cause schizophrenia?

Answer 5

the rare variation, Xq23 region, according to a study done by Kirov et all 52% of people with schizophrenia had this variant - this was not found in 372 controls.

Question 6

what does epigenetics mean?

Answer 6

this refers to a gene only becoming active after an environmental trigger for example, sexual abuse.

Question 7

what did Gottesman and Shields find?

Answer 7

when comparing MZ and DZ twins they found a concordance rate for MZ = 47% and for DZ = 9% when measuring schizophrenia.

Question 8

how might this theory be reductionist?

Answer 8

because they only they don’t consider epigenetics, therefore it could be an environmental factor that triggers the gene rather than just the presence of a gene. this suggests the theory to be simplistic.