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Foundations1 > Genetics > Flashcards

Genetics Flashcards

0
Q

prokaryotes are different b/c

A

no nucleus, haploid, no post-transcription processing

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1
Q

post-trascriptional processing

A

splicing
polyA
5’ cap
intron/exon

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2
Q

ways to modify genes (5)

A
  1. physical modification
  2. chemical modification
  3. transcriptional regulation
  4. posttranscriptional regulation
  5. translation regulation
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3
Q

Physical modification of genes

A
  • dna loss (RBC nucleus extrusion)
  • dna amplifaction
  • dna rearrangement
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4
Q

Chemical modification of genes

A

methylation (CpG islands 5CG3) (globin is methylated in nonhb cells)

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5
Q

Transcriptional regulation of genes

A 
chromatin condensation (histone binds DNA in mature RBC)
regulation via TF
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6
Q

Posttranscriptional regulation of genes

A 
alternnative splicing
altnerative polyadenylation
mRNA editing
mRNA transport
mRNA stability
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7
Q

Translational regulation of genes

A

initiation of protein synthesis: heme regulates globin mRNA translation

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Foundations1 (14 decks)

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