Erythropoiesis Flashcards
What synthesizes globin? what synthesizes heme?
Globin in ribosome
Heme in mitochondria
Where does RBC mature?
Bone marrow: sternum, ribs, pelvis
What removes old RBC? where does it go?What is the system involved?
Macrophages
Spleen, liver, bone marrow
reticuloendothelial system
What is the hormone that starts RBC production? Where does it come from? what does it activate?
Erythropoietin activates JAK2
From kidney
Binds progenitor cell
Maturation process of RBC? Time? Color change?
100 hours in marrow More hemaglobin (blue--> orange) cytoplasm and nucleus smaller rRNA decreases 2 days as reticulocyte in blood
What is a normal RBC concentration in plasma? Rate of production?
4-6 million/microL
2 million/second
Name of process of centrifuge and measure volume of RBC?
Hematocrit
Opposite of anemia?
Polycythemia
Lipids of RBC membrane?
External: PC, sphingomyelin, glycolipids
Internal: PS, PE, PI
Name of proteins on RBC membrane? Function of each?
Flipase: to internal (rapid)
Flopase: to external (slow
Scramblase
Stuff involved in RBC cytosolic skeleton
Spectrin skeleton
Ankyrin, band3, protein 4.2, RH associated glycoproteins
Path: what diseases if you see target cells?
Sickle cell diseases (S and C disease)
Path: what diseases will you see no central pallor?
Membrane abnormalities: hereditary spherocytosis, hereditary ellipotocytosis/ovalocytosis, hereditary pyropoikilocytosis
Path: What disease has fish mouth opening?
Hereditary stomatocytosis (membrane abnormality)
Path: What disease has bite cells?
G6PD deficiency (results in oxidaation of Hb)
