Genetic Diversity And Adaptation Flashcards
Define mutation
Change to quantity or sequence of bases
Define gene mutation
Change to base sequence of DNA
When are gene mutations most likely to occur?
Synthesis phase
What are the types of gene mutations?
Substitution
Deletion
Addition
Describe the difference between the effects of a Deletion and substitution mutation
Deletion causes frame shift so all Amino acids change
Substitution changes one triplet so one Amino acid changed
Describe how deletion can lead to a non functional protein
Frame shift Diff triplets Diff codons and anti codons Diff Amino acids in polypeptide Change to ionic hydrogen and disulphide bond placement Change to tertiary structure Change to shape and function
Define carcinogen
A substance that increases the likelihood of mutations occuring
Name carcinogens
UV radiation
Toxic chemicals
Define chromosome mutation
Change to structure or number of chromosomes
What are the two types of chromosome mutations
Change to whole set of chromosomes
Change to one pair of chromosomes
Name the effects of change to a whole set of chromosomes and why it occurs
Polyploidy
Sister chromatids fail to seperate
Name the effects of change to a one pair of chromosomes and why it occurs
Non-disjunction
Homologous pairs fail to seperate during meisosis
Why is mitosis important
For genetic variation
Allow continuity of diploid number between generations (prevent doubling)
Allow diploid no to be restored upon fertilisation
What occurs to chromosomes during meiosis??
Nuclear envelope disintegrates and chromosomes condense and pair up (crossing over) and spindle fibres develop from centrioles
Spindle fibres attach to centromeres and align pairs at equator of cell. Independent segregation.
Spindle fibres contract and pull homologous chromosomes apart to opposite poles
Spindle fibres disintegrate and nuclear envelope forms, cytokinesis
Occurs again but this time sister chromatids are. Pulled apart and centromeres divide
When does the number of chromosomes half in meiosis (1 or 2)
1