General Cancer Physiology Flashcards
1
Q
When is ATM activated?
A
ATM is activated if a double strand DNA break is detected
2
Q
When is ATR activated
A
ATR is activated when a single stranded break is detected
3
Q
How do oncogenes arise?
A
Oncogenes arise due to mutations of normal proto-oncogenes
4
Q
Tumour supressor genes are
A
genes whose loss or inactivation can trigger cancer development
5
Q
Give 2 examples of gatekeeper genes
A
p53 and APC
6
Q
Role of caretaker genes
A
maintain genetic stability BUT aren’t directly involved in controlling cell proliferation; prevents mutation
