Gene expression Flashcards

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1
Q

All Cells Must Precisely Regulate The Expression Of Genes To

A

Function As Coherent Biological Systems

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2
Q

This Ability Is Essential For All
Cells To Produce The Specific Set
Of Proteins & Specialized RNA
Molecules They Require To
Function

A

Independently As A Single-Cell species &
As A Critical Part Of A Multi-Cell
Species Like Us

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3
Q

Precise Gene Expression Enables Cells To

A

Maintain All Proteins & Specialized RNA Molecules At The
Proper Concentration

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4
Q

Each Of The 220 Human Cell Types Must Express A Unique Pattern Of Genes To

A

Produce The Distinctive Set Of Proteins & Specialized RNA Molecules It Needs To
Perform Its Bodily Function

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5
Q

The Gene Is Activated When The Cell Needs The Protein

A

the Gene Encodes Or Needs A Higher
Concentration

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6
Q

The Gene Is Deactivated When The Cell

A

Does Not Need The Protein The Gene Encodes
* Has The Proper Concentration Of The Protein The Gene Encodes

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7
Q

When A Receptor Recognizes An
Environmental Factor,

A

The Cell
Expresses The Genes That Code For
The Proteins The Cell Requires To
Respond To That Environmental Factor

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8
Q

The Operon

A

Is A Group Of Related Genes Clustered Together On The
Prokaryotic (Archaea & Bacteria) Chromosome

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9
Q

The Genes In The Operon Code For

A

Related Proteins That Perform A Specific
Cellular Function, Such As, Lactose Metabolism
The Lac Operon Of The
Bacterium, E. coli, That
Inhabits Your Lower
Intestine

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10
Q

Arranging Related Genes Into An Operon Facilitates

A

The Expression Of
Gene Regulation, Conserves Energy, And Conserves Molecular
Building Blocks

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11
Q

All Genes In An Operon Are Expressed (Activated) Or Repressed (Deactivated) As A Single
Unit Because

A

One Promoter Controls The Transcription Of All The Operon’s Genes

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12
Q

Only One Molecular Switch Is Required To

A

Regulate Operon Expression

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13
Q

After Translation, All The Proteins Required To
Catabolize Lactose Are

A

Clustered Together In The Cell

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14
Q

The Lac Operon Of The Bacterium Escherichia coli (E. coli

A

-E. coli Inhabits The Lower Human Intestine
- E. coli Has Access To The Nutrients In Breast Milk & Other Dairy Products
-The Lac (Lactose) Operon Enables E. coli To Metabolize Lactose (Milk Sugar)

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15
Q

The Lac Z Gene Codes For The

A

Beta-Galactosidase Enzyme That Cleaves Lactose To
Produce Glucose & Galactose

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16
Q

We Produce Lactase In The Small Intestine To Digest

A

Lactose In Dairy Products

17
Q

The Lac Y Gene Codes For The

A

The Membrane Transport Protein, Permease, That Imports
Lactose

18
Q

The Lac A Gene Codes For

A

Transacetylase Enzyme That Protects The Cell By Detoxifying
Poisonous Β-Galactosides & Increasing Their Export

19
Q

The Promoter & Operator Are

A

The DNA Regulatory Elements That
Control Lac Operon Expression

20
Q

Transcription Factors & RNA Polymerase Bind To

A

The Promoter To Enable
(Promote) Transcription

21
Q

The Regulatory Lac I Repressor Protein Binds To The

A

Operator To Repress
Transcription

22
Q

The Lac I Repressor Protein Is Required For

A

E. coli To Control
Lac Operon Expression

23
Q

This Regulatory Protein Is
Encoded By The Lac I Gene

A

The Lac I Gene Is Not Part Of The
Lac Operon

24
Q

When the Lac I Repressor Protein

A

-Binds To The Operator, The Lac
Operon Is Repressed Because RNA
Polymerase Cannot Bind To The
Promoter
-Does Not Bind To The Operator,
The Lac Operon Is Expressed
Because RNA Polymerase Binds To
The Promoter

25
Q

The Lac Operon Is The

A

First Model Based On Actual Data To Explain
How Cells Regulate Gene Expression

26
Q

When Lactose Is Unavailable,

A

E. coli Represses The Lac Operon

27
Q

Expression Without Lactose Would Waste The?

A

The Resources (Energy, Nucleotides, Amino
Acids) Required To Perform Transcription & Translation

27
Q

he Lac Operon Is

A

Repressed Without Lactose

27
Q

When There Are No Lactose
Molecules In The Bacterium,
The

A

Lac I Repressor Protein Binds To
The Operator
* RNA Polymerase Enzyme
Cannot Bind To The Promoter
* Lac Operon Is “Repressed”

28
Q

The Lac Operon Is Expressed With

A

Lactose In The Cell

28
Q

Lactose Binds To The Lac I Repressor Protein

A

The Lac I Repressor Protein Is Inactivated
* The Inactivated Lac I Repressor Protein Cannot Bind To The Operator
* RNA Polymerase Binds To The Promoter & Transcribes The Three Genes