Gastrointestinal Flashcards
What is hepatitis?
Liver inflammation
What is the pathophysiology of viral hepatitis?
the virus enters the body via various routes, which infect hepatocytes (liver cells).
The immune system responds to infection by activating immune cells (T cells + macrophages) - inflammation occurs in the liver as immune cells infiltrate the tissue to combat the virus
The immune response & viral replication can lead to hepatocyte injury & death
S&S of hepatitis?
often many pt are asymptomatic
or if symptoms present they are either intermittent or ongoing
What is hepatitis A & how do you get it?
- mild/acute liver failure
- not chronic
- incidence decreases with vaccination
- RNA virus transmitted via fecal-oral route
- contaminated food/drinking water
What is hepatitis B & how do you get it?
- acute or chronic
- incidence decreases with vaccination
- DNA virus transmitted = perinatally, percutaneously & via mucosal exposure to infections
- blood & bodily fluids
What is Hepatitis C & how do you get it?
- acute = asymptomatic
- chronic = liver damage
- RNA virus transmitted percutaneously
- IV drug use (share), increase in sexual behaviour, perinatal exposure
What is hepatitis D & how do you get it?
- defective single strand of RNA virus
- needs HEP B to replicate
- transmitted percutaneously (denoting passage of substances through unbroken skin)
- no vaccine
What is hepatitis E & how do you get it?
- RNA virus
- transmitted via fecal-oral or drinking contaminated water
- occurs primarily in developed countries
What are some risk factors for hepatitis
- contaminated food + water
- sexual contact (HEP A+B) w/ multiple partners
- IV drugs + sharing needles
- increase consumption of alcohol
- working in environment where exposed to body fluids
- autoimmune disease
What are the signs & symptoms of Acute phase - incubation phase of hepatitis?
- malaise
- anorexia
- weight loss
- fatigue
- n+v
- abdo discomfort
- joint stiffness
- distaste for cigarettes
- decrease sense of smell
- headache + low grade fever
- skin rash
What are the signs & symptoms of acute phase of hepatitis?
- hepatomegaly
- lymphadenopathy
- splenomegaly
- jaundice
What are the signs & symptoms of of the convalescent phase of hepatitis?
- begins as jaundice leaves (weeks - months)
- malaise + easily fatigued
- hepatomegaly
What are the signs & symptoms of recovery phase of hepatitis?
- homologous immunity to HAV or HBV
- can be reinfected
- most recover completely with no complications
What are the medications/management of hepatitis?
- rest
- administer B-complex vitamins
- ascites
- prevent bleeding/hemorrhage
- hepatic encephalopathy
- nutritional therapy
What should someone avoid if they have hepatitis?
- alcohol
- aspirin
- paracetamol
- NSAIDs
What are nursing priorities for caring someone with hepatitis?
- assessment & monitoring (monitor hepatic function)
- infection control
- pain + symptom management
- nutritional support
- fluid + electrolyte imbalance
- hepatitis vaccine
- pt education
What is crohn’s disease?
Inflammatory bowel disease
- chronic inflammation of the lower GIT characterised by remission & exacerbations
What is the pathophysiology of crohn’s disease?
sharply demarcated grannulamotouse lesions that are surrounded by normal-appearing mucosal tissue
when multiple lesions, the adjacent mesentery may become inflamed & the regional lymph nodes & channels may enlarge
Chronic inflammation of T cells activation leads to tissue injuries
What are the S&S of crohn’s disease?
- diarrhoea
- weight loss
- fatigue
- abdo pain
- fever
What are the risk factors for crohn’s disease?
- <30yrs of age
- family hx
- smoking
- NSAIDs
What are the nursing priorities for someone with crohn’s disease?
- pain assessment
- vital obs
- maintain hydration
- enc. low fiber diet
What medications are used for someone with crohn’s disease?
- anti-inflammatory
- corticosteroids
- immunodulators
- metronidazol
- nutritional supplements
- analgesia