Gastroenterology Flashcards
t/f ALT is a more specific marker for liver damage compared to AST
true
in addition to measuring AST/ALT for suspected liver dysfunction, what else should you measure?
liver synthetic function ( albumin, coags, etc)
if there are mildly elevated liver enzymes on testing, what is the next best step in further evaluation?
repeat the test in 4 weeks
if you have concern for MASLD, then what is the next calculation to do in the evaluation for potential progression to fibrosis?
fibrosis 4 index
if the Fibrosis 4 index is elevated, what is the next step in evaluation?
liver MRI
what 3 medication options should be considered for the MASLD population?
GLP-1, SGLT2, and statins
what AST/ALT ratio is suggestive of alcohol liver disease?
> 2
t/f acetaminophen, Augmentin, sulfonamides, isoniazid and statin are the most common causes of drug induced liver injury
true
if there is suspicion for drug induced liver injury and the offending drug is removed, the AST/ALT should resolve within what period of time?
2-3 months
what is the USPSTF recommendation on general adult hep C screening?
screen adults 18-79 yo
what condition is characterized by hepcidin deficiency?
hereditary hemachromatosis
what are the two tests to perform if concerned about hereditary hemachromotosis?
iron panel and HFE mutation testing
where is A1AT produced?
liver
what is the acute and maintenance treatment for autoimmune hepatitis?
corticosteroid - acute treatment
azathioprine - maintenance treatment
after screening for Wilson’s disease with ceruloplasmin, what is the confirmatory test?
24 hour copper excretion
