Gastritis

Question 1

What’re the 3 types of gastritis?

Answer 1

Autoimmune (type A)
Bacterial (type B)
Chemical type (C)

Question 2

What is type A and what does it do?

Answer 2

Autoimmune
Organ specific 
Autoantibodies to parietal cells and intrinsic factor
Atrophy of acid secreting epithelium 
-decreased acid secretion
-Loss of intrinsic factor

Question 3

Side effect of type A?

Answer 3

Pernicious anemia

-loss of intrinsic factor

Question 4

What causes type B?

Answer 4

Helibacter Pylori

Question 5

Describe H.Pylori and its mechanism of action

Answer 5

Gram -ve
Spiral shaped
Microaerobic, flagellated
Found on gastric mucosa of epithelium, doesn’t penetrate further
Increases acid production by:
-secretes a little ammonia on surface of gastric epithelium
-stomach secretes more acid to get rid of the ammonia
-pH is lowered and there’s more acid than at the start

Question 6

What causes type C?

Answer 6

NSAIDS
Alcohol
Bile reflux

Question 7

Dx/Ix of H.Pylori

Answer 7

Non-invasive

• serology
• urea breath test
• stool antigen test

Invasive

• histology
• -gastric biopsies stained for bacteria
• culture of gastric biopsy
• rapid slide urease test