Gastric Secretion Flashcards
What is the function of the fundus?
Storage
What is the function of the body of the stomach?
Storage, mucus, HCl, pepsinogen and intrinsic factor
What is the function of the antrum of the stomach?
Mixing/grinding and gastrin
What do the parietal cells produce?
HCl and intrinsic factor
What do the chief cells produce?
Pepsinogens
What do the mucous neck cells produce?
Mucus
What mechanisms control gastric acid secretion?
Neurocrine (vagus/local refluxes)
Endocrine (gastrin)
Paracrine (histamine)
What are enterogastrones?
Hormones released from gland cells in duodenal mucosa
What causes the release of enterogastrones?
Acid, hypertonic solutions, fatty acids or monoglycerides in the duodenum
How do enterogastrones prevent acid build up in the duodenum?
They inhibit gastric acid secretion and reduce gastric emptying
What is the function of zymogen?
It binds to pepsin and prevents cellular digestion
What is the role of gastric mucus?
It protects mucosal surface from mechanical injury and gastric acid corrosion
