Gastric Cancer Flashcards
Description: How common is gastric cancer and what histological type make up the majority?
- 2nd most common malignancy in the world
- Most common histological type is adenocarcinoma
Aetiology: What are the causes of gastric cancer?
- H.pylori
- Smoking
- Diet
- Family history/genetics (CDH-1 gene mutation)
- Previous gastric resection
- Gastric polyps
Pathology: State the methods of spread of gastric cancer (4)
- Direct spread (to nearby structures)
- Lymphatic spread (to regional lymph nodes)
- Blood spread (to liver)
- Transcoelomic spread (spread within peritoneal cavity)
Pathology: State the sites of metastasis for gastric cancer (5)
- Lung
- Liver
- Lymph nodes
- Bone marrow
- Peritoneum
Pathology: State 2 types of gastric tumours.
- MALT
- GIST
Pathology: Corea Hypothesis
AAA
Pathology: Metaplasia Dysplasia
AAA
Symptoms: State the symptoms of gastric cancer (8)
- Dyspepsia
- Iron deficiency anaemia
- Vomiting and nausea
- Weight loss
- Early satiety
- GI bleeding
- Gastric outlet obstruction
- Dysphagia
THE SIGNS WERE NOT IN THE LECTURE
THE SIGNS WERE NOT IN THE LECTURE
Investigations: What investigations should be done for gastric cancer
(a) To make a histological diagnosis
(b) To stage the cancer
(c) What should the MDT discuss?
(a) Endoscopy and biopsy
(b) CT of the chest and abdomen (to look for spread of cancer)
(c) Patient fitness, histology and imaging
Treatment: How do we treat gastric cancer? (2)
- Surgery
- Chemotherapy
THE COMPLICATIONS WERE NOT IN THE LECTURE
THE COMPLICATIONS WERE NOT IN THE LECTURE
Extra: In the management of gastric cancer patients, who forms part of the multi-disciplinary team (MDT)?
- Gastroenterologist
- GI surgeon
- Oncologist
- Pathologist
- Radiologist
- Specialist nurses
Extra: Gastric cancer has a early/late presentation in Western countries and a good/poor prognosis
- Late
- Poor
