Gastric 3 Flashcards
Histologic hallmark of Ulcerative Colitis
Crypt abscess
Crypts loaded with neutrophils
Ulcerative colitis always starts in
Presents with pain where?
Rectum
But then moves up to any part of colon (rectum, sigmoid, descending, etc)
Left lower quadrant with bloody diarrhea
Complications of Ulcerative Colitis
Toxic megacolon (with possibility of rupture)
> 10 years, Carcinoma
Colonoscopy will assess of dysplasia
Gross appearance of UC
Psuedopolyps
Loss of Haustra (lead pipe on imaging)
Location of Crohn’s disease
Anywhere from mouth to anus
can skip around (not continuous like UC)
Most and least common site of Crohn’s
most: terminal ileum
least: rectum
presents with RLQ pain
Histologic appearance of Crohn’s
Granulomas
What is creeping fat and strictures?
Inflammation of intestinal wall (transmural: Mucosa, Submucosa, Muscularis Propria, Serosa)
Myeofibroblasts in granulation tissue has contractile function, causing “stricture” reducing the calibre of the lumen. It also pulls the fat from the mesentery closer to the serosa, “creeping fat”
Why does Crohn’s result in kidney stones (nephrolithiasis)?
Calcium oxalate in the bowl usually doesn’t get absorbed, but it can get into blood with inflammation, resulting in accumulation in glomerulus
Crohn’s disease associated with ankylosing spondylitis (which is?)
degenerative systemic Inflammation of the spinal joints resulting in calcification and complete rigidity
Which is more common? Duodenal or Gastric Ulcer?
Symptoms?
Duodenal is 4x more common
Pain more meals or at night
Relieved by eating
Warning indicators for epigastric pain
ALARM Anemia Loss of Weight Anorexia Recent Onset/Progressive Melana/Hematemesis Swallowing Difficulty
Two most common acid blockers
Omeprazole (20mg/24h)
Ranitidine (150mg/12h)
Complications of Primary Biliary Cirrhosis
Osteoperosis
Malabsorption of fat soluble vitamins
What are the fat soluble vitamins?
A
D
E
K
