Gas exchange Flashcards

1
Q

what is pressure?

A

force exerted per unit area. Gas exerts uniform pressure on all surfaces

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2
Q

how do gases exert pressure

A
  1. ) number of molecules that impact container

2. ) strength of impacts (Kinetic energy from temperature)

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3
Q

Ideal gas law

A
PV=nRT 
partial pressure (volume)= (amount of gas)(gas constant 0.082) (temp in kelvin)
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4
Q

boyles law

A

P1V1=P2V2 P∝1/V

at constant temp. pressure of gas is inversely proportional to the volume of gas

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5
Q

charles law

A

V1/T1=V2/T2 V∝T

at constant pressure volume of gas is proportional to temp. of gas

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6
Q

Gay boy lussacs law

A

P1/T1=P2/T2 P∝T

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7
Q

partial pressures of gas

A

N=79% O=21% CO2=.04% (.0004) (to find partial pressures just multiply by atmospheric pressure, but when air is humidified you must subtract partial pressure of h20 first )

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8
Q

henry’s law

A

[gas]=(PPgas)(solubility coefficient)

solubility coefficient is how easy it is for gas to dissolve in solution.

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9
Q

actual/ relative solubility of O2

A

.024/1

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10
Q

actual/ relative solubility of CO2

A

.57/24

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11
Q

actual/ relative solubility of N

A

.01/.5

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12
Q

actual/ relative solubility of He

A

.008/.33

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13
Q

diffusabilty

A

diffusion∝ ((delta P)(Area)(solubility))/((distance)(sqrt molecular weight))
surface area and distance constant for all gases. assuming the same pressure for all gases formula turns into :diffusion∝(solubility)/(sqrt (molecular weight))

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14
Q

movement of gas proportional

A

delta P, surface area, gas solubility,

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15
Q

movement of gas inversely proportional

A

distance, gas molecular weight

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16
Q

saturation

A

percentage of heme molecules bound with O2

oxyhemoglobin vs. deoxyhemoglobin

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17
Q

affinity

A

how easy it is for heme molecules to bind or release O2
high affinity: easy to bind hard to release
low affinity: hard to bind, easy to release

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18
Q

bohr effect

A

changes in [CO2] affects affinity for O2. increased CO2 decreases O2 affinity

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19
Q

haldane effect

A

changes in [O2] affects affinity for CO2. increases O2 decreases CO2 affinity

20
Q

limiting factor of O2 utilization at tissue level

A

ADP

21
Q

CO2 content dissolved in plasma

A

7%

22
Q

total CO2 content bound to hemoglobin

A

23%

23
Q

total CO2 content chemically modified to HCO3-

A

70%

24
Q

Respiration

A

Transport of oxygen and CO2 in opposite direction

25
Q

4 functions of respiration

A

Pulmonary ventilation (moving air between atmos. and alveoli)
Diffusion of O2 and CO2 between alveoli and blood
Transport of O2 and CO2 in blood and body fluids to and from tissue cells
Regulation of ventilation

26
Q

Solubility coefficient

A

How easy it is for gas to dissolve in solution

27
Q

Co2 is … Times more soluble than n2

A

57

28
Q

Co2 is … Times more soluble than helium

A

71

29
Q

Co2 is … Times more soluble than O2

A

24

30
Q

Co2 is times more diff usable from O2

A

20.3

31
Q

Define diffusability

A

Ability of gas to move through tissue and fluid

32
Q

Oxygen gradient from alveoli to blood

A

64-65

33
Q

Factors affecting O2/co2

A

Alveolar epithelial membrane lining,interstitial fluid, capillary membrane,plasma,red cell wall, red cell interior,chemical reaction

  1. ) main player with O2 is alveolar wall
  2. ) main player with co2 is chemical reac. From hco3-
34
Q

Pressure gradient of co2 from blood to alveoli

A

5

35
Q

Why does co2 not need the same pressure gradient as O2 to ensure adequate transfer at tissues?

A

Co2 is a lot more diffusable

36
Q

O2 bound to hemoglobin vs dissolved

A

97/3

37
Q

Non lethal range O2

A

10-1000 mmHG

38
Q

Non lethal range co2

A

5-80 mmHG

39
Q

Non lethal range sodium

A

115-175 mmol/L

40
Q

Non lethal range potassium

A

1.5-9 mmol/L

41
Q

Non lethal range calcium

A

.5-2 mol/L

42
Q

Non lethal range pH

A

6.9-8 pH

43
Q

Arterial /venous pressure of O2

A

95 mmHG vs 40mmHg

44
Q

Arterial venous co2 pressure

A

40/ 45

45
Q

Interstial po2 and Pco2

A

40/45

46
Q

RBC po2 and co2 pressure

A

23/46