Cardiac Contraction Flashcards

1
Q

skeletal muscle contraction and membrane

A

long striated cells with multiple nuclei. contraction initiated by nervous system. membrane contains receptors that stimulate contraction. acetylcholine is neurotransmitter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

smooth muscle contraction and membrane

A

long spindle shaped cells.contraction initiated by nervous system, hormones, stretch of muscle. membrane has receptors that can either stimulate or inhibit contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

cardiac muscle contraction

A

branching striated cells. contraction initiated by specialized cardiac cells (pacemaker)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

myofibrils

A

muscle fibers composed of these. Each one is made up of thick and thin threads called myofilaments

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

myosin filaments

A

thick protein. approx. 1500 per myofibril

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

actin filament

A

thin protein. 3000 per myofibril

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

sarcolemma

A

plasma membrane enclosing muscle fiber. has special cytoplasm called sarcoplasm. within sarcolemma lie numerous mitochondria with large number of myofibrils running parallel

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

intercalated disc

A

hold fibers together and aid of conduction from one fiber to another. unique to cardiac cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

sarcoplasmic reticulum

A

surrounds each myofibril. network of tubes and sacs that hold mad calcium dog.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

t tubles

A

cross sarcoplasmic reticulum at right angles and communicate to outside. easy movement of action potential from exterior to interior of the cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

sarcomere

A

fundamental unit of muscle contraction. extends from z to z line. does work son!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

I band

A

thin actin strands alone (letter I is skinny)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Z line

A

anchor actin filaments composed of filamentous protein (z is last letter of alphabet and last part of sarcomere)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

A band

A

composed of overlapping thick myosin and thin actin myofilaments (length of myosin myofilament)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

H ZONE

A

only myosin strands

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

m line

A

mid line connects adjacent myosin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

titin

A

framework for sarcomere. large protein (3,000,000 daltons). one end anchored to z disk and other is attached to myosin. (springy and changes length as muscle contracts and relaxes)

18
Q

anatomy of actin

A

strands about 1 um long. composed of 2 F- actin molecules wrapped around each other. basic unit F actin is G actin.

19
Q

g actin

A

42,000 daltons. each one has a molecule of ADP attached. site of attachment for myosin cross bridges

20
Q

tropomyosin

A

70,000 daltons, 40 nanometers long. covers active binding sites during resting phase of action potential

21
Q

troponin complex

A

holds tropomyosin in place on the actin. consists of troponin I, T, and C

22
Q

troponin I

A

strong affinity for actin

23
Q

Troponin T

A

strong affinity for tropomyosin

24
Q

Troponin C

A

strong affinity for calcium

25
Q

anatomy of myosin

A

each myosin fiber is a bundle of 200 myosin molecules. each molecule is 480,000 daltons . made of six polypeptide chains 2 heavy (200,000 daltons each) and 4 light (20,000 daltons each)

26
Q

heavy chains of myosin

A

wrapped in double helix and form the tail. one end of each heavy chain is folded to create 2 heads. (each head acts as ATPase enzyme)

27
Q

light chains

A

2 light chains attach to each head to help control action during contraction

28
Q

contraction of sarcomere

A

calcium enters cell and reacts with troponin. tropomyosin undergoes conformational shift in tropomyosin
and exposes binding sites. once actin exposed cross bridges are formed. works like oars on a boat

29
Q

myosin attached to actin at start of cycle

A

myosin head lacks a bound nucleotide and is attached to actin in a rigor state (rigid) very short lived. terminated by binding of ATP

30
Q

Myosin releases actin

A

ATP binding to cleft on back of cause conformational change in actin binding sites. reduces head’s affinity for actin and allows it to move away from actin

31
Q

hyrolysis of ATP on myosin head

A

causes cleft to close like a clam shell around ATP. triggers large shape change that causes head to move along actin about 5nm. ADP and inorganic phospahte remain on head

32
Q

myosin rebinding to actin

A

weak binding of myosin to new site releases inorganic phosphate produced by hydrolysis. head is now able to tightly bind to actin

33
Q

phosphate released- power stroke

A

the release of phosphate triggers the power stroke in which the head regains original conformation. during the course of power stroke the head loses ADP and starts cycle over (rigid again)

34
Q

muscle relaxation

A

calcium transported to SR. tropomysoin blocks actin binding sites. Z lines move further apart

35
Q

tension only

A

isometric. if muscle ends held in place max tension muscle can develop will be represented

36
Q

muscle ends free

A

isotonic (fixed tension) ability to shorten but no tension. shows max velocity of contraction

37
Q

heart develops tension to..

A

overcome given afterload then begins to shorten. both tension and velocity of shortening will be less than max

38
Q

increased contractility results in

A

developing more tension for a given resting tension (changes final muscle length not resting)

39
Q

beta 1 interaction

A

NE and Epi stimulates increased calcium influx during phase 2. increased influx loads calcium channel releases even more calcium on the next depolarizations. calcium removal rate also increases. the duration of the AP is decreased

40
Q

law of Laplace

A

T=P(R)
T=total wall tension P= intraventricular pressure R= ventricular radius
easier to produce pressure at end of ejection than at beginning. dilation plays huge role on pressure generation