Blood numbers (mostly) Flashcards
components of blood
plasma,rbc,wbc,platelets
plasmas percentage of bodyweight/ plasmas total blood volume percentage
4%/54%
red blood cells percentage of total blood volume/concentration
44-45% of total blood volume/3.6x10^6/ul-5.5x10^6/ul
wbc concentration
5-10x10^3/ul or 5000-10000/ul
platelet concentration
150,000-350000/ul
platelets/wbc (buffy coat) percentage of total blood volume
.5-1%
plasma components
90% water 10% solute (proteins,electrolytes,organic compounds)
Amount of proteins in plasma
6.8-8 gm/dl
Amount electrolytes in plasma
900 mg/dl
albumin in plasma/ percentage of total plasma protein
4.5 gm/dl, 62%
globulins in plasma and percentage of total protein in plasma
2.5 gm/dl, 34.2%
fibrinogen in plasma and percentage of total protein in plasma
300 mg/ dl, 4%
MW of albumin
66,000 g/mol
amount of albumin produced by liver everyday
14-17 grams approx 9% of total albumin
alpha 1 globulin percentage of total plasma protein
4%
alpha 2 globulin percentage of total plasma protein
8%
beta globulin percentage of total plasma protein
12%
gamma immunoglobulin percentage of total plasma protein
16% 1.5 gm/dl
globulin functional groups
plasma proteolytic proteins, plasma protease inhibitors, carrier proteins, acute phase proteins
types proteolytic protein systems
complement, kinin,blood coag,fibrinolytic
plasma protein inhibitors
a-macroglobulin, antithrombin 3, c1 inhibitor, a2 plasmin inhibitor
acute phase proteins
hemostatic factors (fibrinogen, van Willenbrand factor),C3 and B components of complement, Haptoglobin, protease inhibitors alpha 1 antichymotripsin, alpha 2 antiplasmin, C reactive protein
dimensions of RBC SHAPE, DIAMETER greatest thickness, least thickness, area volume
biconcave discoid, diameter:8.1 microns, greatest thickness: 2.7 microns, least thickness 1.0 micron, area 138 microns^2, volume 95 microns ^3
RBC contents by volume percentage
water= 70%, 25% hemoglobin, 5% other
ionic concentrations in blood for: sodium, potassium, chloride, bicarbonate, protein
18 mEq/l, 81 mEq/l, 52 mEq/l, 19 mEq/l, 5 mMol/L
of molecules in RBC
300 million
total O2 CONTENT DISSOLVED IN PLASMA
2%
henrys law
(O2 dis)=(PO2)(.003 ml O2/dl/mmHg)
percentage of O2 bound to Hb
98%
importance of Ca, K, Na
normal impulse conduction in nerves and muscle fibers
importance of Ca
coagulation and cardiac muscle contraction
importance of K
maintains cardiac rhythm
Importance of cl
replaces bicarbonate ions taken-up by RBCs
chloride shift
importance of Na Cl
maintains fluid balance between blood & body tissues
importance of Mg
promotes normal neuromuscular function
importance of bicarbonate
not electrolyte –maintains normal acid- base status – major body buffer
homozygous S production of Hb vs heterozygous
100% Hb S, vs. 40 % Hb S and 60% Hb A
percentages of wbc count
neutrophils 60-70%, eosinophils 2-4 %, basophils .5-1%, monocytes 3-8 % , lymphocytes 20-25%
neutrophil sensitivity to chemotactic molecules
1 billionth of a mole or 1 nM
neutrophilic structure and concentration
10-15 microns in diameter, polymorhonuclear (2-5 lobes ont the nucleus), approx 5,500/ul
eosinophils diameter and concentration
12-17 microns in diameter, approx 10-760/ul
basophils diameter and concentration
5-7 microns in diameter 10-250/ul
monocyte diameter and concentration
12-20 microns, 20-1000/ul
lymphocyte concentration and diameter
650-4500/ul (with T cells being 75% of that), 5-12 microns
platelet diameter and concentration
2-4 microns 250,00/ul
daily production erythrocytes
3 x 10^9/kg of body weight
daily production granulocytes
1.6 x 10^9
daily production monocytes
1.7x 10^8a
daily production eosinophils basophils and lymphocytes
variable, unknown
daily production platelets
2.8 x10^9
Type A percentage of pop.
41%
percentage of pop. Type B
9%
percentage of pop. Type AB
3%
percentage of pop. Type O
47%
percentage of pop. D+/Rh+
85%
whole blood/ packed cells temp. and shelf life
1-6 degrees celsius, refrigerated shelf life of 21 days( CPD/CP2D), 35 days CPDA-1)
pack cells shelf life
42 days
platelets shelf life and temp
20-24 degrees C SHELF LIFE OF 5 days while being slowly rocked
plasma shelf life and temp
frozen at -18 degrees celsius, shelf life of 1 year