Future Of Ageing Flashcards
How much of death and disability cause are chronic disease?
70% WHO 2005
Why are timescales an issue within finding a cure for, ageing ?
Even if we discover a mean to charge it for the better it would take many years for it to become apparent.
What would success in finding reliable biomarkers of ageing enable?
Early evaluation of interventions go improve healthy life expectancy
Personalised monitoring of ageing-related health trajectories
What the blood based biomarkers?
• Haematology
• nutritional markers
• inflammatory response
• lymphocyte subpopulations
• telomere length
• DNA damage and repair
• plasma isoprostanes
What are the biomarker-changes in anthrometry, blood pressure and physical function?
• Weight & fat
• diastolic and systolic blood pressure
• hand-grip strength
•Tug test
• respiratory function
What is the species problems within studying ageing with using animal models?
Short-lived animals are more have a greater need for adjusting to short- term changes
The more dramatic effects on ageing in animal models are linked to their evolved capacity for plasticity which is not reproduced in humans.
What are the challenges in extending the human health span?
Timescales
The species problems
Measurements
Trials and regulations
Side-effects
What was the issue with trials and regulations within extending the human health plan?
Would have very strict regulatory controls
Would require clinical trails
Approving drugs for treatment would take very many years as they would be given to healthy people.
What are the issues with side effects in extending the human health span?
High chances any interventions that can modulate intrinsic ageing will evoke potent side effects.
Issues of safety and acceptability.
What is a silver community?
Private expenditure by older people (50+) on various goods and services.
After what age does no one have perfect health?
After 85
What was the effect of calorie defficit in mice models?
Calorie restriction can reduce the speed of ageing.
Why do the people in Okinawa live longer?
Eat a mediterrian diet and very little fat.
What was the biosphere 2 experiment?
Scientist living in a huge glass dome (like the simpsons)
What was the result of the biosphere 2 experiment?
Tried to be self sufficient
Couldn’t grow own good very well
This went on for years
People had better health profiles
