Fungi 2 Flashcards
What is an example of a superficial mycosis? What does it infect?
- Dermatophytosis
- superficial keratin structures - produces keratinases
What are sympoms of Dermatophytosis?
Tinea (jock’s itch, althlete’s foot, ringworm)
How is Dermatophytosis (a superficial mycosis) spread? How is it treated?
spread: fomites, autoinnoculation
treated: topical azole (or orally with griseofulvin)
Do superficial mycoses require thermal dimorphism?
No
How are subcutaneous mycoses introduced? How do they spread from the site of introduction?
-Introduced: trauma exposing subcu tissue to soil or vegetation
Spread: Lymphatics - toward trunk
Do subcutanous mycoses have thermal dimorphism?
Yes
How are most cases of sporotrichosis, a subcutaneous mycosis, treated? How are serious cases treated?
-Most: oral azoles
Serious: Amphotericin B (polyene), local surgery
What fungus causes Sporotrichosis, a subcutaneous mycosis?
Sporothix spp
Do Systemic mycoses have thermal dismorphism?
Yes
Are systemic mycoses transmissible from person to person?
No
How is coccidioides, a systemic mysosis, acquired?
spores inhaled
How is coccidioides, a systemic mycosis, treated in various ways?
-predisposed to complications: oral azoles
-meningitis: fluconazole
pregnant or disseminated: amphotericin B (polyene)
What distinguishes mild, moderate, and severe coccidioides, a systemic mycosis?
- mild: asymptomatic or flu-like
- moderate: valley fever/dessert rheumatism (pulmonary + EN)
- severe: pneuomonia or dissemination
What can systemic mycoses mimc? What is the difference?
- TB
- American soil vs foreign crowds
How are opportunistic mycoses treated?
- based on pre-existing conditions
- treat infection and underlying problem
