Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Microbiology Unit 2 > DNA Viruses 1 > Flashcards

DNA Viruses 1 Flashcards

You may prefer our related Brainscape-certified flashcards:
Biology 101 flashcards
1
Q

What are two DNA viruses?

A

Adenovirus, papillomavirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Where does txn and replication of DNA virus genomes occur? What is the excetion?

A

Nucleus

Poxvirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What enzyme transcribes the DNA virus mRNA? What is the exception?

A

host RNA pol

Poxvirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What enzyme replicates a DNA viral genome?

A

viral OR host DNA pol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the steps in DNA virus replication?

A 
Recognition of target cell
Attachment
Entry: Penetration or Fusion
Uncoating
Transcription of mRNA (host RNA Pol)
Protein synthesis
Replicate genome (host or viral DNA pol)
Assembly of virions
Egress: lysis, budding, exocytosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How does a DNA virus enter a cell?

A

Penetration or Fusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How do DNA viruses egress?

A

lysis, budding, or exocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What host machinery recognizes viral promoters?

A

RNA Pol II and txn factors (X,Y)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What to viral txn factors do?

A

Work WITH host txn factors
also virulence factors
might be essential proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is an example of a virus which uses host DNA pol for replication? How is this virus characterized?

A

Parvovirus

Adeno-assiciated virus 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Do DNA viruses which use host/virus DNA Pol have small/large genomes?

A

use host - small genome - don’t encode

use own - large genome - encode enzyme

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are examples of viruses which encode their own DNA pol?

A

Herpesvirus

Adenovirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What DNA viruses are the most common causes of disease?

A

Adenovirus
Papillomavirus
Herpesvirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What respiratory illnesses does the Adenovirus cause?

A

bad cold with fever
pharyngoconjunctival fever
laryngitis and cough
pneumonia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What non-respiratory illnesses does the Adenovirus cause?

A

Acute hemorrhagic cystitis
Epidemic keratoconjunctivitis
Gastroenteritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the transmission of the Adenovirus?

A

aerosol, fecal-oral, objects

poorly chlorinated pools

17
Q

What populations are susceptible to adenovirus?

A

children

military recruits

18
Q

What are sites of outbreak of the adenovirus?

A

daycare centers
swim clubs
“boot camp”

19
Q

How does the adenovirus bind to the cell receptor?

A

fiber protein

20
Q

How does adenovirus enter the cell?

A

Endocytosis

21
Q

After endocutosis, how does adenovirus get out of the vesicle?

A

endosome acidification lyses vesicle

22
Q

When and where does adenovirus uncoating happen?

A

after edosome is lysed, capsid goes to nucleus

DNA genome uncoats through nuclear pore

23
Q

What are the gene expression phases of adenovirus?

A

Immediate early
Early
late

24
Q

Where does the adenovirus capsid assemble?

A

nucleus

25
Q

How do adenovirus virions egress?

A

lysis

26
Q

What is the diagnosis of adenovirus?

A

culture
antigen detection
PCR
serology

27
Q

What is the treatment of adenovirus?

A

Only treat dire cases in immunocompromised patients

Cidofovir (but it’s nephrotoxic)

28
Q

How is adenovirus prevented? What population receives this?

A

Vaccine

military personnel

29
Q

What is the most commonly diagnosed STI in the US?

A

HPV

30
Q

What epithelial diseases does human Papilloma virus cause?

A 
Verruca vulgaris (common warts)
Verruca planaris (plantar warts)
Condyloma acuminata (genital warts)
31
Q

What malignancies does human papilloma virus cause?

A

head and neck cancer
cervical cancer
penile cancer

32
Q

What is the tissue tropism of HPV? What layer must it reach?

A

differentiated epithelial cells

basal

33
Q

How does HPV-induced malignancy occur?

A

oncogene activation

34
Q

How many types of HPV are high risk for cancer?

A

13

35
Q

What is the diagnosis of HPV?

A

recommended for genital

DNA test for type

36
Q

What is the treatment for warts?

A

Excision

  • cryotherapy (freezing)
  • chemical ablation (salicylic acid, etc)
  • colposcopy (minor surgery of cervix)
37
Q

How are HPV malignancies treated?

A

oncotherapy

38
Q

what is the prevention of HPV?

A

vaccines

  • Gardasil (6, 11, 16, 18)
  • Cervarix (16, 18)
39
Q

How were the vaccines for HPV created?

A

both are VLP’s (virus-like particles)

empty capsid

Microbiology Unit 2 (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions